Şişman, PınarAykurt, Ayşen2024-01-112024-01-112018-03Şişman, P. vd. (2018). ''The effect of primary hyperparathyroidism on pancreatic exocrine function''. Journal of Endocrinological Investigation, 41(3), 293-298.1720-8386https://doi.org/10.1007/s40618-017-0727-6https://link.springer.com/article/10.1007/s40618-017-0727-6https://hdl.handle.net/11452/38960Background Elastase-1 is a proteolytic enzyme secreted by pancreatic acinar cells, and measurements of the concentration this enzyme are used to evaluate pancreatic exocrine function. We aimed to determine whether pancreatic exocrine function declines due to chronic hypercalcemia by measuring fecal elastase levels. Methods 75 patients with primary hyperparathyroidism (18 men and 47 women) and 30 healthy subjects (11 men and 19 women) participated in this study. Renal function tests, lipid parameters, bone mineral density, and serum calcium, phosphorus, vitamin D, parathormone, glucose, and thyroid stimulating hormone levels as well as fecal elastase concentrations, were determined in these patients and controls. Results The mean fecal elastase level was 335.3 +/- 181.4 mu g/g in the PHPT group and 317.4 +/- 157.3 mu g/g in the control group. There was no significant difference in fecal elastase levels between the two groups (p = 0.5). Conclusions Chronic hypercalcemia in primary hyperparathyroidism did not decrease the fecal elastase level, which is an indirect indicator of chronic pancreatitis; therefore, chronic hypercalcemia in PHPT may not cause chronic pancreatitis.eninfo:eu-repo/semantics/closedAccessEndocrinology & metabolismPrimary hyperparathyroidismFecal elastasePancreatic exocrine functionsBone-mineral densityFecal elastase-1InsufficiencyAdultAgedAged, 80 and overBiomarkersCase-control studiesExocrine pancreatic insufficiencyFecesFemaleFollow-up studiesHumansHypercalcemiaHyperparathyroidism, primaryMaleMiddle agedPancreatic elastasePancreatitis, chronicPrognosisArticle0004260438000032-s2.0-8502677224829329841328770447Endocrinology & metabolismExocrine Pancreatic Insufficiency; Chronic Pancreatitis; SecretinCalciumGlucoseLipidPancreatic elastaseParathyroid hormonePhosphorusThyrotropinVitamin D.Biological markerPancreatic elastaseAdultAgedArticleBone densityCalcium blood levelChronic pancreatitisClinical evaluationControlled studyEnzyme blood levelExocrine pancreatic insufficiencyFeces analysisFemaleGlucose blood levelHumanHypercalcemiaKidney function testLipid blood levelMajor clinical studyMalePancreas secretionParathyroid hormone blood levelPhosphate blood levelPrimary hyperparathyroidismThyrotropin blood levelVitamin blood levelCase control studyChronic pancreatitisComplicationEnzymologyExocrine pancreatic insufficiencyFecesFollow upHypercalcemiaMetabolismMiddle agedPathophysiologyPrimary hyperparathyroidismPrognosisVery elderly