Sudha, ThangiralaBharali, Dhruba JDarwish, Noureldien H.E.Keating, Kelly ALin, Hung-YunDavis, Paul J.Mousa, Shaker A2022-11-042022-11-042017-02Sudha, T. vd. (2017). ''Targeted delivery of cisplatin to tumor xenografts via the nanoparticle component of nano-diamino-tetrac''. Nanomedicine, 12(3), 195-205.1743-58891748-6963https://doi.org/10.2217/nnm-2016-0315https://www.futuremedicine.com/doi/10.2217/nnm-2016-0315http://hdl.handle.net/11452/29376Aim: Nano-diamino-tetrac (NDAT) targets a receptor on integrin alpha v beta 3; alpha v beta 3 is generously expressed by cancer cells and dividing endothelial cells and to a small extent by nonmalignant cells. The tetrac (tetraiodothyroacetic acid) of NDAT is covalently bound to a poly(lactic-co-glycolic acid) nanoparticle that encapsulates anticancer drugs. We report NDAT delivery efficiency of cisplatin to agent-susceptible urinary bladder cancer xenografts. Materials & methods: Cisplatin-loaded NDAT (NDAT-cisplatin) was administered to xenograft-bearing nude mice. Tumor size response and drug content were measured. Results: Intratumoral drug concentration was up to fivefold higher (p < 0.001) in NDAT-cisplatin-exposed lesions than with conventional systemic administration. Tumor volume reduction achieved was NDAT-cisplatin > NDAT without cisplatin > cisplatin alone. Conclusion: NDAT markedly enhances cisplatin delivery to urinary bladder cancer xenografts and increases drug efficacy.eninfo:eu-repo/semantics/openAccessBiotechnology & applied microbiologyScience & technology - other topicsCisplatinIntegrinNanotetracNDATTetraiodothyroacetic acidUrinary bladder carcinomaActivated protein-kinaseTetraiodothyroacetic acidThyroid-hormoneCancer-cellsPlatinumIntegrinReceptorGrowthDrugsAnimalsAntineoplastic agentsCell culture techniquesCell lineTumorCell survivalCisplatinDrug delivery systemsDrug liberationFemaleHeterograftsHumansIntegrin alphabeta3Lactic acidMice, nudeNanoparticlesNeoplasm transplantationParticle sizePolyglycolic acidSurface propertiesUrinary bladder neoplasmsArticle0003956749000062-s2.0-8501038321719520512328102776Biotechnology & applied microbiologyNanoscience & nanotechnologyIntegrin; Thyroid Hormones; Nano-Diamino-TetracAcetic acid derivativeCisplatinNanocarrierNanodiaminotetracNanoparticlePolyglactinTetraiodothyroacetic acidUnclassified drugAntineoplastic agentLactic acidPolyglycolic acidPolylactic acid-polyglycolic acid copolymerVitronectin receptorAnimal experimentAnimal modelAnimal tissueArticleBladder cancerCancer sizeControlled studyCovalent bondDrug delivery systemDrug dosage form comparisonDrug efficacyDrug responseDrug tissue levelFemaleHumanHuman cellMouseNanoencapsulationNonhumanTumor xenograftAnimalBladder tumorCancer transplantationCell culture techniqueCell survivalChemistryDrug delivery systemDrug releaseMetabolismNude mouseParticle sizeSurface propertyTumor cell lineXenograftCisplatin