Koz, GamzeKoz, Ömer2022-12-192022-12-192016-04-22Koz, G. vd. (2016). "Enantioselective synthesis of 2-amino-4-(nitromethyl)-4H-chromene-3-carbonitriles from 2-iminochromenes". Synthetic Communications, 46(10), 909-915.0039-79111532-2432https://doi.org/10.1080/00397911.2016.1177728https://www.tandfonline.com/doi/full/10.1080/00397911.2016.1177728http://hdl.handle.net/11452/29963A series of medicinally important 2-amino-4-(nitromethyl)-4H-chromene-3-carbonitriles were synthesized using enantioselective conjugate addition of nitromethane to 2-iminochromenes. The reactions were performed using L8-Cu (II) catalytic system and moderate to good enantioselectivities (62-88%) and yields (66-96%) were obtained.eninfo:eu-repo/semantics/closedAccessChemistryAmino alcohol catalystEnantioselective conjugate addition2-iminochromeneNitromethaneAsymmetric conjugate additionMichael additionPrivileged structuresEfficientDerivativesNitroalkanesApoptosisChromeneSalicylaldehydesMalononitrileArticle0003781478000072-s2.0-849731295369099154610Chemistry, organicDihydropyrano(2,3-C)Pyrazole; Catalyst; BenzopyransAmineChromene derivativeCopperCyanideImineNitro derivativeNitromethaneArticleCatalysisCatalystConjugationEnantioselectivityQuantum yieldReaction analysisSynthesis