2023-04-142023-04-142019-05Dündar, H. Z. vd. (2019). ''Overexpression of miR-21 Is Associated With Recurrence in Patients With Hepatitis B Virus-Mediated Hepatocellular Carcinoma Undergoing Liver Transplantation''. Transplantation Proceedings, 51(4), 1157-1161.0041-13451873-2623https://doi.org/10.1016/j.transproceed.2019.01.089https://www.sciencedirect.com/science/article/pii/S0041134518316610http://hdl.handle.net/11452/32395Bu çalışma, 18-21 Ekim 2018 tarihleri arasında Trabzon[Türkiye]’da düzenlenen 12. Congress of the Turkish-Transplantation-Centers-Coordination-Association (TTCCA)’da bildiri olarak sunulmuştur.Liver transplantation (LT) is the best treatment option for hepatitis B virus (HBV)e mediated hepatocellular carcinoma (HCC). Nevertheless, recurrence is the most important issue after LT. The aims of the present study were to evaluate the relation of dysregulated expression of microRNAs (miRNAs) in recurrence formation in HBV-mediated HCC cases. A total of 42 HBV-mediated HCC patients were evaluated in this study. Among 21 miRNAs, the expression level of miR-106a and miR-21 were higher and miR-143 and miR145 were lower in patients with HCC compared with noncancerous liver tissues (P = .0388, P = .0214, P = .0321, and P = .002, respectively). Compared with nonrecurrent patients, the expression level of miR-21 was 3.54-fold higher and miR-145 was 2.42-fold lower in patients with recurrence during the 5-year follow-up (P = .004 and P = .032; respectively). In addition, according to multivariate Cox regression analysis, the overexpression of miR-21 was found to be a prognostic indicator in HBV-mediated HCC patients (P = .002). In conclusion, we show a significant association between high expression of miR-21 and recurrence in HBV-mediated HCC. Therefore, up-regulation of miR-21 could serve as a promising prognostic marker for HCC.eninfo:eu-repo/semantics/closedAccessImmunologySurgeryTransplantationMicrornasBiomarkersExpressionPrognosisDiagnosisAdultBiomarkers, TumorCarcinoma, HepatocellularFemaleHepatitis BHepatitis B virusHumansLiver NeoplasmsLiver TransplantationMaleMicroRNAsMiddle AgedNeoplasm Recurrence, LocalPrognosisArticle0005001793000332-s2.0-850655700591157116151431101191ImmunologySurgeryTransplantationCirculating Microrna; Biomarkers; Hepatitis B VirusMicroRNAMicroRNA 106aMicroRNA 10bMicroRNA 122MicroRNA 139MicroRNA 143MicroRNA 145MicroRNA 147MicroRNA 148bMicroRNA 155MicroRNA 181MicroRNA 195MicroRNA 19aMicroRNA 21MicroRNA 210MicroRNA 214MicroRNA 22MicroRNA 221MicroRNA 223MicroRNA 24MicroRNA 26aMicroRNA 27Unclassified drugMicroRNAMIRN21 microRNA, humanTumor markerAdolescentAdultAgedArticleCancer prognosisCancer recurrenceClinical articleCinical evaluationCohort analysisControlled studyDisease associationFemaleFollow upGene expression levelGene overexpressionGenetic associationHepatitis B virusHumanHuman tissueLiver cell carcinomaLiver tissueLiver transplantationMalePriority journalQualitative analysisReverse transcription polymerase chain reactionUpregulationBiosynthesisComplicationGeneticsHepatitis BHepatitis B virusLiver cell carcinomaLiver tumorMiddle agedPathologyPrognosisTumor recurrence