2021-11-262021-11-262008Akdag, İ. vd. (2008). ''Clinical value of the malnutrition-inflammation-atherosclerosis syndrome for long-term prediction of cardiovascular mortality in patients with end-stage renal disease: A 5-year prospective study''. Nephron Clinical Practice, 108(2), C99-C105.1660-2110https://doi.org/10.1159/000113526https://www.karger.com/Article/Fulltext/113526http://hdl.handle.net/11452/22829Background/Aim: Mortality resulting from cardiovascular disease in patients with end-stage renal disease (ESRD) is high. In this study we sought to investigate the clinical value of the malnutrition-inflammation-atherosclerosis (MIA) syndrome for long-term prediction of cardiovascular mortality in patients treated with ESRD. Methods: A total of 42 ESRD patients on hemodialysis were enrolled. Inflammatory markers and nutritional parameters were determined. Carotid atherosclerosis was investigated by ultrasonographically evaluated carotid intima-media thickness (cIMT). Mortality was evaluated at a 5-year follow-up. Results: No correlation was evident between nutritional markers and inflammatory indexes. cIMT was inversely correlated with predialysis serum albumin. In the overall population of 42 patients, 11 (26.2%) died of cardiovascular causes during follow-up. Kaplan-Meier survival curves indicate that cIMT (>= 0.9 mm), C-reactive protein (CRP) (>1 mg/dl), and serum albumin (<3.5 g/dl) predict cardiovascular death in patients with ESRD. Conclusions: We have demonstrated that cIMT, CRP and serum albumin predict long-term mortality in ERSD patients. Our study suggests that further investigation of the MIA syndrome will provide insights into the susceptibility to CVD in this patient group.eninfo:eu-repo/semantics/closedAccessEnd-stage renal diseaseHemodialysisCardiovascular diseaseInflammationMalnutritionMortalityMarkersNutritionHemodialysis-patientsUrology & nephrologyAdultAgedAnthropometryAtherosclerosisC-Reactive proteinCardiovascular diseasesCarotid arteriesFemaleHumansInflammationKaplan-meiers astimateKidney failure, chronicMaleMalnutritionMiddle agedProspective studiesRenal dialysisRisk factorsSerum albuminStatistics, nonparametricSyndromeArticle0002532472000032-s2.0-39549093606C99C105108218212491Urology & nephrologyHemodialysis; Wasting; Dialysis PatientsAlbuminC reactive proteinSerum albuminAdultArticleAtherosclerosisClinical articleControlled studyEchographyFemaleFollow upHumanInflammationKaplan meier methodkidney failureMaleMalnutritionMortalityPriority journalAgedAnthropometryAtherosclerosisBloodCardiovascular diseaseCarotid arteryChronic kidney failureInflammationMalnutritionMiddle agedNonparametric testPathologyProspective studyRenal replacement therapyRisk factorSyndrome