2022-08-162022-08-162014-06Bağdaş, D. vd. (2014). "Antinociceptive effect of chlorogenic acid in rats with painful diabetic neuropathy". Journal of Medicinal Food, 17(6), 730-732.1096-620X1557-7600https://doi.org/10.1089/jmf.2013.2966https://www.liebertpub.com/doi/10.1089/jmf.2013.2966?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmedhttp://hdl.handle.net/11452/28192The present study aimed to evaluate possible antinociceptive effects of chlorogenic acid in streptozotocin-induced diabetic neuropathic pain in rats. Chlorogenic acid (100 mg/kg) was administered daily for 14 days. Our study showed for the first time that both single and chronic chlorogenic acid treatments produced significant antinociceptive effects in diabetic rats. In contrast, single dose of chlorogenic acid showed no signs of an antinociceptive effect, but chronic treatment exerted antinociceptive potential in nondiabetic rats. Additionally, chronic treatment effectively reduced hyperglycemia that induced by diabetes. In conclusion, chlorogenic acid has beneficial effects for the management of diabetic neuropathic pain.eninfo:eu-repo/semantics/closedAccessAntihyperalgesicAntinociceptiveChlorogenic acidDiabetesDiabetic neuropathyPainPharmacology & pharmacyFood science & technologyNutrition & dieteticsAnalgesicsAnimalsChlorogenic acidDiabetes mellitus, experimentalDiabetic neuropathiesHyperglycemiaHypoglycemic agentsMalePhytotherapyPlant extractsRats, wistarArticle0003379035000142-s2.0-8490244145573073217624611441Chemistry, medicinalFood science & technologyNutrition & dieteticsAntioxidant; Carlina Oxide; LoniceraChlorogenic acidGlucoseAnalgesic agentAntidiabetic agentChlorogenic acidPlant extractAnimal experimentAnimal modelAntidiabetic activityAntinociceptionArticleControlled studyGlucose blood levelHyperalgesiaHyperglycemiaLong term careNeuropathic painNonhumanPriority journalRatSingle drug doseStreptozotocin-induced diabetic neuropathyTreatment durationAnimalComplicationDiabetic neuropathiesExperimental diabetes mellitusMalePhytotherapyWistar rat