Özmen, Suay2022-01-102022-01-102011-07Özmen, S. vd. (2011). "Effects of levobupivacaine versus bupivacaine infiltration on postoperative analgesia in pediatric tonsillectomy patients: A randomized, double-blind, placebo-controlled study". Annals of Otology, Rhinology and Laryngology, 120(7), 489-493.0003-48941943-572Xhttps://journals.sagepub.com/10.1177/000348941112000712http://hdl.handle.net/11452/23965https://doi.org/10.1177/000348941112000712Objectives: We compared the effects of levobupivacaine hydrochloride, bupivacaine hydrochloride, and saline injections in alleviating posttonsillectomy pain. Methods: Between November 2009 and April 2010, we recruited 60 patients (36 male and 24 female) between 2 and 12 years of age into the study. After informed consent was obtained from the parents, patients admitted for tonsillectomy were randomized into 3 groups by means of sealed envelopes. Group 1 (20 patients; mean age, 6.45 +/- 2.78 years) received 0.9% sodium chloride (saline solution), group 2 (20 patients; mean age, 5.60 +/- 2.70 years) received 0.25% levobupivacaine hydrochloride, and group 3 (20 patients; mean age, 5.85 +/- 2.43 years) received 0.5% bupivacaine hydrochloride infiltrated around each tonsil. Pain was evaluated with McGrath's face scale. Results: The postoperative pain scores at 1 and 5 hours were similar among the groups (p > 0.05). The pain scores in the levobupivacaine group were lower than those in the saline group at 13 hours (p < 0.017). The pain scores in the bupivacaine and levobupivacaine groups were significantly lower than those in the saline group from 17 to 21 hours until day 6 (p > 0.017). There was no difference between the levobupivacaine and bupivacaine groups (p > 0.017). Conclusions: Local infiltration of levobupivacaine is a relatively safe and effective method and is equivalent to use of bupivacaine for posttonsillectomy pain.eninfo:eu-repo/semantics/closedAccessOtorhinolaryngologyBupivacaineInfiltrationLevobupivacainePainTonsillectomyPeritonsillar infiltrationPain reliefChildrenRopivacaineReductionParalysisTonsilsArticle0002929515000122-s2.0-79960187416489493120721859060OtorhinolaryngologyTonsillectomy; Palatine Tonsil; Postoperative HemorrhageBupivacaineLevobupivacaineSodium chlorideAirway obstructionAnesthesia complicationArticleBleedingChildControlled studyDehydrationDrug efficacyDrug safetyFemaleFeverHalitosisHumanHypertrophyMajor clinical studyMaleMcgrath face scaleOtalgiaPain assessmentPostoperative analgesiaPostoperative nausea and vomitingPostoperative painPreschool childPriority journalRandomized controlled trialRating scaleSchool childTonsil diseaseTonsillar hypertrophyTonsillectomyTonsillitisTrismus