Akpınar, Gürler2022-01-182022-01-181999-01Egeli, Ü. vd. (1999). "In vivo dominant lethal effect of pyrimethamine in male mouse germ cells". Mutagenesis, 14(1), 67-69.0267-8357https://doi.org/10.1093/mutage/14.1.67https://academic.oup.com/mutage/article/14/1/67/1077521http://hdl.handle.net/11452/24141Pyrimethamine is used for treatment of malaria and toxoplasmosis. The embryotoxicity and clastogenicity of pyrimethamine is known and our aim was to investigate its dominant lethal effect in vivo. For this purpose, we used three groups of Swiss-albino male mice and a control group. We injected males with doses of 16, 32 or 64 mg/kg pyrimethamine and housed them with 10 females/male for each mating interval. Females were sacrificed and their uteri were evaluated for dominant lethality. As a result of this study we found that pyrimethamine induced dominant lethal mutations in the third, fourth and sixth weeks at the 64 mg/kg dose level, without the effect being dose-dependent. We conclude that pyrimethamine is a suspected germ cell mutagen.eninfo:eu-repo/semantics/openAccessGenetics & heredityToxicologyCHL cellsInductionAcidRatsAnimalsEmbryoFemaleGene expression regulation, developmentalGenes, dominantGenes, lethalGerm cellsMaleMiceMutagenesisMutationPregnancyPyrimethamineTime factorsArticle0000783437000102-s2.0-0032965171676914110474824Genetics & heredityToxicologyHyperpigmentation; Vitamin B 12 Deficiency; Megaloblastic AnemiaMutagenic agentPyrimethamineAnimal cellAnimal experimentAnimal tissueArticleControlled studyDominant lethal mutantDominant lethal testEmbryotoxicityFemaleGerm cellIn vivo studyMaleMatingMouseNonhumanPriority journalUterus biopsy