2021-09-132021-09-132001-02-28Güleç, G. ve Noyan, B. (2002). "Do recurrent febrile convulsions decrease the threshold for pilocarpine-induced seizures? Effects of nitric oxide". Developmental Brain Research, 126(2), 223-228.0165-3806https://doi.org/10.1016/S0165-3806(01)00098-0https://www.sciencedirect.com/science/article/pii/S0165380601000980http://hdl.handle.net/11452/21905The aim of the study was to determine whether (1) number of febrile convulsions is a predictor of development of temporal lobe epilepsy, (2) the susceptibility of rats to pilocarpine-induced seizures is increased due to febrile convulsions and (3) nitric oxide is a mediator in the pathogenesis of febrile convulsions. Rat pups were exposed to single or multiple hyperthermic seizures. Subconvulsant doses of pilocarpine (100 mg/kg and 150 mg/kg) were injected intraperitoneally to these rats at 60-70 days of age. Also L-arginine was applied to some rats before a single hyperthermic seizure. We found that risk of future epilepsy increases parallel to the number of febrile convulsions and nitric oxide does not have a pathogenetic role at given doses.eninfo:eu-repo/semantics/closedAccessPilocarpineRatSeizureSusceptibilityResistantHyperthermia-induced seizuresTemporal-lobe epilepsyStatus epilepticusLong-termRat susceptibilityChildhoodGlutamateSystemHyperthermia, inducedAnimalsArginineBehavior, animalBody temperatureDisease models, animalDisease progressionDisease susceptibilityDose-response relationship, drugElectroencephalographyEpilepsy, temporal lobeNitric oxideImmersionInjections, intraperitonealPilocarpineRatsRats, wistarReaction timeRisk assessmentSeizuresSeizures, febrileArticle0001676629000112-s2.0-0035961404223228126211248357Developmental biologyNeurosciencesFebrile Seizures; Status Epilepticus; Iron-Deficiency Anemias