Selimoğlu, HadiDuran, Cevdet2021-10-212021-10-212010-04Selimoğlu, H. vd. (2010). "The effect of vitamin D replacement therapy on insulin resistance and androgen levels in women with polycystic ovary syndrome". Journal of Endocrinological Investigation, 33(4), 234-238.0391-40971720-8386https://doi.org/10.1007/BF03345785https://link.springer.com/article/10.1007/BF03345785https://doi.org/10.1007/10.3275/6560http://hdl.handle.net/11452/22427Insulin resistance (IR) is one of the common features of the polycystic ovary syndrome (PCOS), and recent studies indicate the possible role of vitamin D in the pathogenesis of IR and glucose metabolism. Aim of this study was aimed to determine the effect of vitamin D replacement therapy on glucose metabolism, insulin, and androgen levels in obese, insulin-resistant women with PCOS. Eleven women with PCOS were included in the study. Mean age of the patients was 23.6+/-5.7 yr, body mass index 33.9+/-5.1 kg/m(2). Six patients (54.5%) had acantosis nigricans and 10 (90.9%) oligoamenorrhea. The mean Ferriman Gallwey score was 14.1+/-4.6. Only 2 women were within the normal limits of vitamin D levels as >20 ng/ml. Three weeks after the administration of the single dose of 300,000 units of vitamin D3 orally, 25-hydroxyvitamin D3 significantly increased from 16.9+/-16 ng/ml to 37.1+/-14.6 ng/ml (p: 0.027) and only 2 women were detected to have vitamin D3 levels <20 ng/ml. Although glucose and insulin levels were decreased non-significantly, homeostasis model assesment (HOMA)-IR significantly decreased from 4.41+/-1.38 to 3.67+/-1.48 (p: 0.043). No significant alterations were witnessed at the levels of DHEAS, total and free testosterone, androstenedione. No correlation was found between vitamin D with HOMA and other hormonal parameters. In conclusion, women with PCOS have mostly insufficient vitamin D levels, and vitamin D replacement therapy may have a benefical effect on IR in obese women with PCOS.eninfo:eu-repo/semantics/closedAccessInsulin resistancePolycystic ovary syndromeVitamin DGlucose metabolismAndrogenLong-term treatmentGlucose-toleranceHypovitaminosis-DObese womenSensitivitySecretion1,25-dihydroxyvitamin-D3PrevalenceReceptorTestosteroneEndocrinology & metabolismAdolescentAdultAndrogensAnimalsBlood glucoseFemaleHumansInsulinInsulin resistanceObesityPolycystic ovary syndromeVitamin DVitaminsYoung adultArticle0002785707000062-s2.0-7795356205823423833419820295Endocrinology & metabolismOvary Polycystic Disease; Ergocalciferols; Calcitriol ReceptorsAndrogenAndrostenedioneGlucoseInsulinPrasteroneTestosteronevitamin DGlucose blood levelVitaminAcanthosis nigricansAdultArticleBody massClinical articleCorrelation analysisFemaleGlucose metabolismHumanInsulin resistanceObesityOligomenorrheaOvary polycystic diseaseScoring systemSubstitution therapyAdolescentAnimalBloodGlucose blood levelInsulin resistanceMetabolismPhysiologyPolycystic ovary syndromeYoung adult