2022-08-162022-08-162007Ursavaş, A. vd. (2007). "Circulating ICAM-1 and VCAM-1 levels in patients with obstructive sleep apnea syndrome". Respiration, 74(5), 525-532.00257931https://doi.org/10.1159/000097770https://www.karger.com/Article/FullText/97770http://hdl.handle.net/11452/28213Background: Obstructive sleep apnea syndrome (OSAS)-induced hypoxic stress modulates circulating inflammatory mediators causing accelerated atherogenesis. Objectives: We hypothesized that OSAS-induced hypoxia might result in cardiovascular disease due to increased expression of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) on the endothelial surface. Methods: Thirty-nine subjects with moderate-to-severe OSAS and 34 non-apneic controls matched for age, gender, body mass index (BMI), smoking history, and cardiovascular disease were included in this prospective study. Overnight polysomnography was performed. Circulating ICAM-1 and VCAM-1 levels in the serum were measured by enzyme-linked immunosorbent assay. Results: Circulating levels of both ICAM-1 (480.1 +/- 216.7 vs. 303.4 +/- 98.6 ng/ml, p < 0.0001) and VCAM-1 (1,156.6 +/- 79.8 vs. 878.8 +/- 71.1 ng/ml, p = 0.002) were significantly increased in the OSAS group compared to the control group. For an ICAM-1 cutoff level of 375 ng/ml, predictive sensitivity and specificity for OSAS were 69.2% (95% confidence interval, CI: 52.4-83.0%) and 82.4% ( 95% CI: 65.5-93.2%), respectively. For a VCAM-1 cutoff level of 859 ng/ml, predictive sensitivity and specificity for OSAS were 74.4% (95% CI: 57.9-86.9%) and 64.7% ( 95% CI: 46.5-80.2%), respectively. There was a significant positive correlation between circulating levels of ICAM-1 and ln of AHI (r = 0.276, p = 0.018). Multiple logistic regression analyses showed that OSAS was associated with high ICAM-1 and high VCAM-1 levels independent of age, gender, BMI, smoking status and cardiovascular disease. Conclusion: We conclude that OSAS can independently increase circulating levels of adhesion molecules.eninfo:eu-repo/semantics/closedAccessAdhesion moleculesCardiovascular disordersHypoxiaInflammatory mediatorsObstructive sleep apnea syndromeCoronary-artery diseaseIntercellular-adhesion molecule-1Apparently healthy-menCardiovascular-diseaseRisk-factorsE-selectinEndothelial-cellsCytokine levelsHeart-diseaseAtherosclerosisIntercellular adhesion molecule-1AdultFemaleHumansLogistic modelsMaleMiddle agedMultivariate analysisROC curveSleep apnea, obstructiveVascular cell adhesion molecule-1Article0002511380000082-s2.0-3454762410152553274517148932Respiratory systemObstructive Sleep Apnea; Positive End Expiratory Pressure; Pressure TreatmentFemaleAdultArticleCardiovascular diseaseClinical articleControlled studyDisease severityEnzyme linked immunosorbent assaySleep apnea syndromeHumanHypoxiaMalePolysomnographyPriority journalProtein expressionIntercellular adhesion molecule 1Vascular cell adhesion molecule 1