Bridoux, AlexandreCui, HuadongDyskin, Evgeny A.Mousa, Shaker A.2021-12-102021-12-102009-06-15Bridoux, A. vd. (2009). "Semisynthesis and pharmacological activities of tetrac analogs: Angiogenesis modulators". Bioorganic and Medicinal Chemistry Letters, 19(12), 3259-3263.0960-894Xhttps://doi.org/10.1016/j.bmcl.2009.04.094https://www.sciencedirect.com/science/article/pii/S0960894X09006040http://hdl.handle.net/11452/23162Novel Tetrac analogs were synthesized and then tested. Anti-angiogenesis efficacy was carried out using the Chick Chorioallantoic Membrane (CAM) model and the mouse matrigel model for angiogenesis. Pharmacological activities showed Tetrac can accommodate numerous modifications and maintain anti-angiogenesis activity.eninfo:eu-repo/semantics/closedAccessAngiogenesisEsterificationHPLCNanopharmaceutical technologySilylationTetracIntegrin alpha-v-beta-3Extracellular segmentCrystal-structureTriiodothyronineThyroxineLigandAcidPharmacology & pharmacyChemistryAngiogenesis inhibitorsAnimalsChick embryoChorioallantoic membraneDrug evaluation, preclinicalFibroblast growth factorsHemoglobinsMiceStructure-activity relationshipThyroxineArticle0002664020000242-s2.0-6574909962632593263191219427201Chemistry, medicinalChemistry, organicTetraiodothyroacetic Acid; Thyroid Hormones; Nano-Diamino-TetracAngiogenesis inhibitorFibroblast growth factorIodine derivativePhenol derivativeAngiogenesisAnimal experimentAntiangiogenic activityArticleChick embryoChorioallantoisControlled studyDrug efficacyDrug potencyDrug synthesisEmbryoMaleMouseNonhumanStructure activity relation