Özgür, TanerÇakır, Esra D. P.2024-03-192024-03-192015-11Çakır, E. D. P. vd. (2015). "Retrospective evaluation of pubertal development and linear growth of girls with Turner Syndrome treated with oral and transdermal estrogen". Journal of Pediatric Endocrinology and Metabolism, 28(11-12), 1219-1226.0334-018X2191-0251https://hdl.handle.net/11452/40500https://www.degruyter.com/document/doi/10.1515/jpem-2014-0007/htmlObjective: The objective of the study was to evaluate the pubertal development and linear growth of Turner Syndrome (TS) girls regularly monitored in our department. Patients and methods: The data of 13 patients with TS were evaluated retrospectively. Left hand radiograms were evaluated by three different pediatric endocrinologists to determine bone ages. Results: Six (46.2%) of the TS girls were treated with oral estrogens, while 7 (53.8%) were treated with transdermal estrogen. The ratios of chronological age (CA) difference to bone age (BA) difference (Delta CA/Delta BA) in two groups of patients treated with estrogen were compared at the time of the last control. The Delta CA/Delta BA ratio in the transdermal estrogen-treated group was significantly higher (p=0.005). These results suggest slower BA progression in the TS girls treated with transdermal estrogen. Conclusion: BA advancement is less significant with transdermal estrogen, which is associated with adequate breast development.eninfo:eu-repo/semantics/closedAccessEndocrinology & metabolismPediatricsEstrogen/gestagen supplementationPubertal hormone replacement therapyTransdermal estradiolTurner syndromeHormone treatmentFinal heightInductionTherapyReplacementManagementEstradiolWomenAdministration, cutaneousAdministration, oralAdolescentBody heightChildEstradiolEstrogensFemaleHumansPubertyRetrospective studiesTreatment outcomeTurner syndromeArticle0003650446000052-s2.0-84947443466121912262811-1225968434https://doi.org/10.1515/jpem-2014-0007Endocrinology & metabolismPediatricsTurner syndrome; Sex chromosome aberrations; Gonadal agenesisEstradiolEstrogenAdolescentArticleBody growthBone ageBreast developmentChildClinical articleEndocrinologistEstrogen therapyEvaluation studyFemaleHand radiographyHumanPubertyRetrospective studyTransdermal patchTurner syndromeBody heightCutaneous drug administrationDrug effectsOral drug administrationPathophysiologyPhysiologyPubertyTreatment outcomeTurner syndrome