Yılmaz, MuratKeegan, Mark T.Vlahakis, Nicholas E.Afessa, BekeleHubmayr, Rolf D.Gajic, Ognjen2022-09-162022-09-162007-10Yılmaz, M. vd. (2007). "Six-month survival of patients with acute lung injury: Prospective cohort study". Critical Care Medicine, 35(10), 2303-2308.0090-3493https://doi.org/10.1097/01.CCM.0000284505.96481.24https://journals.lww.com/ccmjournal/Fulltext/2007/10000/Six_month_survival_of_patients_with_acute_lung.12.aspxhttp://hdl.handle.net/11452/28776Objective: Both short- and long-term outcome studies in acute lung injury (ALI) performed thus far were conducted before the implementation of recent advances in mechanical ventilation and supportive care and/or in the context of clinical trials with restricted inclusion criteria. We sought to determine the outcome of consecutive acute lung injury patients after the implementation of these interventions. Design: Prospective cohort study. Setting: Three intensive care units of two tertiary care hospitals. Patients: Patients with acute lung injury treated from October 2005 to May 2006, excluding those with no research authorization or do-not-resuscitate order. Interventions: None. Measurements and Main Results: The investigators collected detailed information about comorbidities, severity of pulmonary and nonpulmonary organ failures, complications, respiratory support, and other interventions. The main outcome measure was mortality 6 months after the onset of acute lung injury. From 142 patents enrolled over a 6-month period, 24 (17%) died in the intensive care unit, 38 (27%) in the hospital, and 55 (39%) by the end of the 6-month follow-up. Median (interquartile range) intensive care unit length of stay, duration of mechanical ventilation, and number of day 28 ventilator-free days were 7.1 (3.6-11.3), 5.7 (2.6-10.3), and, 19.0 (0-24.2) days. Multiple logistic regression analysis identified underlying Charlson comorbidity score (odds ratio 3.11, 95% confidence interval 2.01-5.05) for each point increase, transfer admission from the floor or outside hospital (odds ratio 3.75, 95% confidence interval 1.41-10.99), day 3 cardiovascular failure (odds ratio 3.30, 95% confidence interval 1.19-9.92), and day 3 Pao2/Fio2 (odds ratio 0.94,95% confidence interval 0.88-0.99) as significant predictors of 6-month mortality. Conclusions: With the implementation of recent advances in mechanical ventilation and supportive care, premorbid condition is the most important determinant of acute lung injury survivaleninfo:eu-repo/semantics/closedAccessOutcome assessmentRespiratory-distress-syndromeAcute lung injuryCohortIntensive care unitsRisk factors prognosisQuality-of-lifeCritically Ill patientsIntensive-care unitsNoninvasive ventilationMechanical ventilationMultivariate-analysisSeptic shockOutcomesMortalitySurvival rateAgedFemaleHumansMaleMiddle agedProspective studiesSevere acute respiratory syndromeTime factorsArticle0002499385000112-s2.0-3474882502023032308351017944018Critical care medicineAdult Respiratory Distress Syndrome; Acute Lung Injury; Tidal VolumeComorbidityAcute lung injuryAdultAgedArticleArtificial ventilationCardiovascular diseaseCohort analysisFemaleOxygen tensionConfidence intervalControlled studyCritically ill patientDisease severityMaleMultiple organ failureFollow upHeart failureHumanIntensive care unitMajor clinical studyPriority journalProspective studySurvival timeTertiary health care