2022-12-282022-12-282016-05-18Sağ, S. vd. (2017). ''Association of monocyte to HDL cholesterol level with contrast induced nephropathy in STEMI patients treated with primary PCI''. Clinical Chemistry and Laboratory Medicine, 55(1), 132-138.1434-6621https://doi.org/10.1515/cclm-2016-0005https://www.degruyter.com/document/doi/10.1515/cclm-2016-0005/html1437-4331http://hdl.handle.net/11452/30143Background: Contrast induced nephropathy (CIN) has been proven to be a clinical condition related to adverse cardiovascular outcomes. In recent studies, the monocyte to high density lipoprotein ratio (MHR) has been-postulated as a novel parameter associated with adverse renal and cardiovascular outcomes. In this study we-investigated the association of MHR with CIN in-ST-segment elevation myocardial infarction (STEMI) patients treated with primary percutaneous coronary intervention (PCI). Methods: Consecutive STEMI patients treated with primary PCI were prospectively recruited. Subjects were categorized into two groups; as patients who developed CIN (CIN+) and patients who did not develop CIN (CIN-) during hospitalization. CIN was defined as either a 25% increase in serum creatinine from baseline or 44.20 mu mol/L increase in absolute value, within 72 h of intravenous contrast administration. Results: A total number of 209 patients were included in the study. Thirty-two patients developed CIN (15.3%). In the CIN (+) patients, monocytes were higher [1.02 (0.83-1.39) vs. 0.69 (0.53-0.90) 109/L, p < 0.01] and HDL cholesterol levels were lower [0.88 (0.78-1.01) vs. 0.98 (0.88-1.14) mmol/L, p < 0.01]. In addition, MHR was significantly higher in the CIN (+) group [1.16 (0.89-2.16) vs. 0.72 (0.53-0.95) 10(9)/mmol, p < 0.01]. In multivariate logistic regression analysis, MHR, Mehran score, AGEF score and CV/eGFR were independently correlated with CIN. Conclusions: Higher MHR levels may predict CIN development after primary PCI in STEMI patients.eninfo:eu-repo/semantics/closedAccessMedical laboratory technologyContrast induced nephropathyHDL-cholesterolMonocytePercutaneous coronary interventionAcute kidney injuryHigh-density-lipoproteinElevation myocardial-infarctionCreatinine clearance ratioPrimary angioplastyCardiovascular eventsN-acetylcysteineRenal-functionRisk scoreAgedCholesterol, HDLContrast mediaFemaleHumansKidney diseasesMaleMiddle agedMonocytesPercutaneous coronary interventionROC curveST elevation myocardial infarctionArticle0003889307000232-s2.0-8499863641213213855127331308Medical laboratory technologyContrast Induced Nephropathy; Coronary Angiography; Kidney DiseasesAcetylsalicylic acidClopidogrelCreatinineHeparinHigh density lipoprotein cholesterolIohexolContrast mediumHigh density lipoprotein cholesterolAdultAgedAGEF scoreArticleContrast induced nephropathyControlled studyCoronary angiographyCoronary stentingCorrelation analysisCreatinine blood levelEstimated glomerular filtration rateFemaleHospitalizationHumanLoading drug doseMajor clinical studyMaleMehran scoreMiddle agedMonocyteMultivariate logistic regression analysisPercutaneous coronary interventionPercutaneous transluminal angioplastyPriority journalProspective studyScoring systemST segment elevation myocardial infarctionBloodChemically inducedCytologyKidney diseasesMonocyteReceiver operating characteristicST elevation myocardial infarction