Etöz, Abdullah2021-11-242021-11-242012-01Özgenel, G. Y. ve Etöz, A. (2012). "Effects of repetitive injections of hyaluronic acid on peritendinous adhesions after flexor tendon repair: A preliminary randomized, placebo-controlled clinical trial". Ulusal Travma ve Acil Cerrahi Dergisi-Turkish Journal of Trauma & Emergency Surgery, 18(1), 11-17.1306-696Xhttps://doi.org/10.5505/tjtes.2012.95530https://jag.journalagent.com/travma/pdfs/UTD_18_1_11_17.pdfhttp://hdl.handle.net/11452/22786The aim of this study was to investigate the efficacy of three injections of hyaluronic acid (HA) versus placebo (saline) over a two-week period on functional outcomes after zone-II flexor tendon repairs. METHODS Twenty-two patients with isolated zone-II flexor tendon injury of the index fingers were included in this study. Before tenorrhaphy, fingers were randomly divided into two groups; 11 were treated with three injections of HA around the tenorrhaphy site and 11 served as a placebo group and were treated with saline in the same way. The first dose was given at the time of tenorrhaphy and two additional doses were given at one-week intervals. A Kleinert rehabilitation protocol was employed postoperatively. Range of motion was assessed with total active and passive movement evaluation systems at 3 weeks, 3 months and long-term. Functional outcome was evaluated using the Strickland classification. RESULTS There were no differences between the two groups in terms of range of motion at 3 weeks. However, at 3 months and long-term, a significant improvement was observed in fingers treated with HA compared to placebo. CONCLUSION This preliminary placebo-controlled study suggests that repetitive injections of HA can improve clinical outcomes presumably due to the effect on decreasing adhesions in primary tendon repairs.eninfo:eu-repo/semantics/openAccessEmergency medicineAdhesion preventionHyaluronic acidTendon adhesionsTendon repairZone-IIIn-vitroRabbitsSurgerySutureMotionFluidPhagocytosisMobilizationInhibitionArticle0003005217000042-s2.0-84855794686111718122290044Emergency medicineFlexors; Tendon Injuries; GappingHyaluronic acidSodium chlorideAdultArticleClinical articleControlled studyDrug efficacyFemaleFlexor tendonFlexor tendon injuryHumanIndex fingerMaleOutcome assessmentPassive movementRandomized controlled trialRange of motionTendon suture