Boisson, Stephanie DupuisKreins, Alexandra Y.Grant, Audrey V.Abel, LaurentCasanova, Jean-Laurent2021-12-012021-12-012012-06Kılıç, S. Ş. vd. (2012). "A patient with tyrosine kinase 2 deficiency without hyper-IgE syndrome". Journal of Pediatrics, 160(6), 1055-1057.0022-3476https://doi.org/10.1016/j.jpeds.2012.01.056https://www.sciencedirect.com/science/article/pii/S002234761200114Xhttps://pubmed.ncbi.nlm.nih.gov/22402565/http://hdl.handle.net/11452/22929We describe a Turkish patient with tyrosine kinase 2 deficiency who suffered from disseminated Bacille Calmette-Guerin infection, neurobrucellosis, and cutaneous herpes zoster infection. Tyrosine kinase 2 deficiency should be considered in patients susceptible to herpes viruses and intramacrophage pathogens even in the absence of atopy, high serum IgE, and staphylococcal disease.eninfo:eu-repo/semantics/openAccessPediatricsMutationsImmunityDock8ChildDiagnosis, differentialFollow-up studiesHumansImmunologic deficiency syndromesJob's syndromeMagnetic resonance imagingMaleTyk2 kinaseArticle0003043773000342-s2.0-8486001511410551057160622402565PediatricsJob Syndrome; Mucocutaneous Candidiasis; Gain of Function MutationAciclovirBcg vaccineCefuroximeClindamycinCotrimoxazoleFocal adhesion kinase 1Immunoglobulin eIsoniazidPyrazinamideRifampicinStreptomycinAdultAnamnesisArticleAtopic dermatitisAudiometryBacillus calmette guerin infectionBacterial infectionBlood cell countBrucellosisCase reportChildClinical featureComputer assisted tomographyElectroencephalographyEnzyme deficiencyHearing aidHerpes virusHerpes zosterHistopathologyHumanHyper Ige syndromeKidney functionLiver functionLymphadenopathyMacrophageMaleNuclear magnetic resonance imagingPhysical examinationPreschool childPriority journalSchool childSkin testStaphylococcus infectionThorax radiography