Alpay, Melih2023-09-262023-09-262017-07-02Özmen, Ö. A. vd. (2018). ''Prognostic significance of soft tissue deposits in laryngeal carcinoma''. Brazilian Journal of Otorhinolaryngology, 84(5), 566-573.1808-86941808-8686https://doi.org/10.1016/j.bjorl.2017.07.002https://www.sciencedirect.com/science/article/pii/S1808869417301167http://hdl.handle.net/11452/34052Introduction: Soft tissue deposits is tumorous islands apart from lymph nodes and occasionally diagnosed in neck dissection specimens. Their importance has begun to be recognized, however, their value has not been investigated in laryngeal cancer as a single tumor site. Objective: To investigate the prognostic value of soft tissue deposits in patients with laryngeal carcinoma. Methods: Medical records of 194 patients with laryngeal carcinoma who were treated primarily by surgery and neck dissection were reviewed. Prognostic significance of soft tissue deposits was assessed along with other clinical and pathological findings. Recurrence rates, overall and disease-specific survival rates were examined. Results: The incidence of soft tissue deposits was found to be 7.2% in laryngeal carcinoma. N stage was more advanced in patients who had soft tissue deposits. Regional recurrence rate was higher and disease specific and overall survivals rates were significantly lower in patients with soft tissue deposits in univariate analysis. However, in multivariate analysis, soft tissue deposits were not found as an independent risk factor. Conclusion: In laryngeal carcinoma, soft tissue deposits was diagnosed in patients with more advanced neck disease and their significance was lesser than other factors including extranodal extension.Resumo Introdução: Depósitos de tecido mole são ilhas tumorais diferente dos linfonodos e ocasionalmente diagnosticados em amostras de esvaziamento cervical. Sua importância começou a ser reconhecida, mas seu valor não foi investigado no câncer de laringe como um único local de tumor. Objetivo: Investigar o valor prognóstico do depósito de tecido mole em pacientes com carcinoma laríngeo. Método: Os prontuários de 194 pacientes com carcinoma laríngeo tratados principalmente por cirurgia e esvaziamento cervical foram analisados. O significado prognóstico dos depósitos de tecido mole foi avaliado juntamente com outros achados clínicos e histopatológicos. As taxas de recidiva, as taxas de sobrevida geral e específicas da doença foram avaliadas. Resultados: Observou-se uma incidência de depósitos de tecido mole de 7,2% no carcinoma laríngeo. O estágio N foi mais avançado em pacientes com depósitos de tecido mole. A taxa de recorrência regional foi maior e as taxas de sobrevida geral e específica da doença foram significativamente menores nesses pacientes na análise univariada. No entanto, na análise multivariada, o depósito de tecido mole não foi observado como um fator de risco independente. Conclusão: No carcinoma laríngeo, o depósito de tecido mole foi diagnosticado em pacientes com doença cervical mais avançada, mas sua significância foi menor do que outros fatores, inclusive a extensão extranodal.eninfo:eu-repo/semantics/openAccessOtorhinolaryngologyLaryngeal cancerSoft tissue depositCervical metastasisPrognosisSurvivalSquamous-cell carcinomaExtracapsular spreadPerineural invasionCancerHeadMetastasesAdultAgedAged, 80 and overBrazilCarcinoma, squamous cellFemaleHumansLaryngeal neoplasmsLymphatic metastasisMaleMiddle agedNeck dissectionPrognosisRisk factorsSoft tissue neoplasmsSurvival rateArticle0004463053000072-s2.0-8502747003356657384528823696OtorhinolaryngologyNeck Dissection; Squamous Cell Carcinoma Of Head And Neck; Sentinel Lymph Node BiopsyArticleCancer prognosisCancer recurrenceCancer survivalDisease specific survivalDistant metastasisFemaleHumanHuman cellHuman tissueLarynx carcinomaMajor clinical studyMaleNeck dissectionOverall survivalPeroperative complicationRetrospective studySecond cancerSmokingSoft tissue cancerSoft tissue depositSurgical marginAdultAgedBrazilEpidemiologyLarynx tumorLymph node metastasisMiddle agedMortalityPathologyPrognosisRisk factorSecondarySoft tissue tumorSquamous cell carcinomaSurvival rateVery elderly