2021-11-122021-11-122006Aydoğan, K. vd. (2006). ''Adult-onset Langerhans cell histiocytosis confined to the skin''. Journal of the European Academy of Dermatology and Venereology, 20(7), 890-892.0926-99591468-3083https://doi.org/10.1111/j.1468-3083.2006.01566.xhttps://onlinelibrary.wiley.com/doi/10.1111/j.1468-3083.2006.01566.xhttp://hdl.handle.net/11452/22640Langerhans cell histiocytosis (LCH) is a clonal, pleo-morphic disease of unknown aetiology, with theaccumulation of local or disseminated atypical histiocyticcells staining positively for S-100 and CD-1a, and causingdamage in the bones, lungs, mucocutaneous structuresand endocrine organs.1 The condition is generally dia-gnosed in infancy and childhood, but onset in adulthoodcan occasionally occur. The eruption is usually diffuse ormanifests as part of a multisystemic disease, and up to 25–50% of patients with LCH will present initially with acutaneous rash.1–5 Cutaneous manifestations are hetero-genous and similar both in children and adults.1,2 LCHconfined to the skin is uncommon among reported casesof adults.2–8 We describe a rare case of adult-onset LCHpresenting as cutaneous lesions located symmetrically onthe scalp, groin and inframammarian areas, and review theliterature for previous adult cases of isolated cutaneousLCH.eninfo:eu-repo/semantics/closedAccessDermatologyCutivateDeltacortrilSkin diseasesHumansHistiocytosis, langerhans-cellFemaleAge of onsetAdultArticle0002391522000342-s2.0-3374630895889089220716898928DermatologyLangerhans Cell Histiocytosis; Eosinophilic Granuloma; HistiocytesPrednisoloneFluticasone propionateDeltacortrilSkin ulcerSkin tumorSkin inflammationSkin biopsyScalpPriority journalOnset ageLetterInguinal regionImmunohistochemistryImmunofluorescenceHumanHistiocytosisFemaleErosionElectron microscopyCase reportBreastAdult