2024-10-142024-10-142017-08-102218-4333https://doi.org/10.5306/wjco.v8.i4.329https://hdl.handle.net/11452/46355Patients treated with platinum-based chemotherapy frequently experience neurotoxic symptoms, which may lead to premature discontinuation of therapy. Despite discontinuation of platinum drugs, these symptoms can persist over a long period of time. Cisplatin and oxaliplatin, among all platinum drugs, have significant neurotoxic potential. A distal dose-dependent symmetrical sensory neuropathy is the most common presentation of platinum neurotoxicity. DNA damage-induced apoptosis of dorsal root ganglion (DRG) neurons seems to be the principal cause of neurological symptoms. However, DRG injury alone cannot explain some unique symptoms such as cold-aggravated burning pain affecting distal extremities that is observed with oxaliplatin administration. In this article, we briefly reviewed potential mechanisms for the development of platinum drugs-associated neurological manifestations.eninfo:eu-repo/semantics/closedAccessRoot ganglion neuronsOxaliplatin-induced neurotoxicityInduced peripheral neurotoxicityNerve hyperexcitabilityAnticancer drugUp-regulationIn-vitroCisplatinNeuropathyDnaCisplatinDorsal root ganglionMechanismOxaliplatinNeurotoxicityNeuropathic painSodium channelScience & technologyLife sciences & biomedicineOncologyReview0004155767000033293358410.5306/wjco.v8.i4.329