2021-10-142021-10-142006Taş, S. vd. (2006). ''Vanadyl sulfate treatment improves oxidative stress and increases serum paraoxonase activity in streptozotocin-induced diabetic rats''. Nutrition Research, 26(12), 670-676.0271-5317https://doi.org/10.1016/j.nutres.2006.09.022https://www.sciencedirect.com/science/article/pii/S0271531706002387http://hdl.handle.net/11452/22343Vanadyl sulfate (VS) may reduce oxidative stress related to its hypoglycemic and hypolipidemic effects in diabetes mellitus; besides, as a catalytic element, it may induce lipid peroxidation. Studies investigating effects of VS on the oxidative-antioxidative systems in diabetes yielded conflicting results, and this study was designed to investigate the effects of VS on the oxidative-antioxidative systems in streptozotocin-induced (65 mg/kg) diabetic rats. Vanadyl sulfate was administered in drinking water 0.75 mg/mL during 5 weeks after the induction of diabetes. Thirty-two male Wistar rats were randomly divided into four groups: control (C), control + vanadyl sulfate (C + VS), diabetes (D), and diabetes + vanadyl sulfate (D + VS). Vanadyl sulfate reduced the enhanced glucose, lipid, and tissue malondialdehyde levels and increased the reduced serum paraoxonase and arylesterase activity in the D + VS group. Plasma malondialdehyde level was significantly increased in the C + VS group, compared with the control group. Erythrocyte glutathione peroxidase activity was significantly higher in the C + VS and D + VS groups, compared with the C and the D groups, respectively.The results of the present study suggest that (i) VS has antioxidative potential in streptozotocin-treated rats, and it might be used as a supportive therapeutic agent in uncontrolled diabetes; (ii) VS treatment might play a role in the improvement of serum paraoxonase activity and, thus, inhibit the progression of atherosclerosis; (iii) the prooxidant potential of the VS should be taken into account.eninfo:eu-repo/semantics/closedAccessNutrition & dieteticsVanadyl sulfateStreptozotocinParaoxonaseOxidative stressDiabetesAminoguanidineSusceptibilityLDLAntioxidant statusAutoxidative glycosylationGlucose autoxidationLipid-peroxidationIn-vivoPlasmaMellitusRattus norvegicusArticle0002431684000102-s2.0-338452838896706762612Nutrition & DieteticsBis(Acetylacetonato)Oxovanadium(IV); Vanadium Compounds; Oxovanadium IVVanadyl sulfateSuperoxide dismutaseStreptozocinMalonaldehydeLipidInsulinGlutathione peroxidaseGlucoseDrinking waterCarbohydrateAryldialkylphosphataseAlpha tocopherolVitamin blood levelTreatment outcomeTherapy effectStreptozocin diabetesSpecies comparisonRatRandomizationAnimal experimentPriority journalOxidative stressNonhumanMaleAnimal modelAnimal tissueAntioxidant activityLipid peroxidationArticleLipid blood levelControlled studyCoronary artery atherosclerosisDiabetogenesisInsulin blood levelGlucose blood levelEnzyme blood levelDisease courseEnzyme activityDug inhibitionDrug effect