Algın, OktayAlgın, Efnan2022-01-202022-01-202010-11Algın, O. vd. (2010). "Role of duplex power doppler ultrasound in differentiation between malignant and benign thyroid nodules". Korean Journal of Radiology, 11(6), 594-602.1229-69292005-8330https://doi.org/10.3348/kjr.2010.11.6.594https://www.kjronline.org/DOIx.php?id=10.3348/kjr.2010.11.6.594http://hdl.handle.net/11452/24181Objective: To evaluate the usage of duplex power Doppler ultrasound (PDUS) for the differentiation of benign and malignant thyroid nodules. Materials and Methods: We prospectively examined 77 thyroid nodules in 60 patients undergoing ultrasound-guided fine needle aspiration biopsy (FNAB). Each nodule was described according to size, inner structure, borders, parenchymal echogenicity, peripheral halo formation, and the presence of calcification (B-mode ultrasound findings). Vascularity as determined by PDUS imaging was defined as non-vascular, peripheral, central, or of mixed type. For each nodule, the pulsatility index (PI) and resistive index (RI) values were obtained. Results of FNAB and surgical pathological examination (if available) were used as a proof of final diagnosis to categorize all nodules as benign or malignant. A receiver operating characteristic (ROC) curve analysis was performed to establish cut-off, sensitivity, and specificity values associated with RI-PI values. Results: A significant relationship was observed between malignancy and irregular margins, microcalcifications, and hypoechogenicity on ultrasound examination (p < 0.05). The pattern of vascularity as determined by PDUS analysis was not a statistically significant criterion to suggest benign or malignant disease in this study (p > 0.05). The central, peripheral, and mean RI-PI values were higher in malignant nodules when compared to the other cytologies (p < 0.05). Conclusion: Vascularity is not a useful parameter for distinguishing malignant from benign thyroid nodules. However, RI and PI values are useful in distinguishing malignant from benign thyroid nodules.eninfo:eu-repo/semantics/openAccessThyroid cancerThyroid nodulesPower doppler ultrasonography, RI, PINeedle-aspiration-cytologyPredictive-valueSonographic criteriaIodine intakeUSRiskUltrasonographyDiognasisPrevalenceParametersRadiology, nuclear medicine & medical imagingAdultAgedBiopsy, fine-needleChi-square distributionDiagnosis, differentialFemaleHumansMaleMiddle agedProspective studiesROC curveSensitivity and specificityStatistics, nonparametricThyroid neoplasmsThyroid noduleUltrasonography, doppler, duplexUltrasonography, interventionalArticle0002846562000022-s2.0-7844927474459460211621076584Radiology, nuclear medicine & medical imagingThyroid Nodule; Fine Needle Aspiration Biopsy; Elasticity Imaging TechniquesAdultAgedAnalytical parametersArticleAspiration biopsyB scanCalcificationClinical trialControlled clinical trialControlled studyDiagnostic accuracyDifferential diagnosisDoppler echographyFemaleHistopathologyHumanHuman tissueImage analysisMajor clinical studyMalePhysical examinationProspective studyPulsatility indexResistive indexSensitivity and specificityThyroid calcinosisThyroid cancerThyroid noduleTumor vascularizationTumor volume