2022-11-182022-11-182015-10-24Başkan, E. B. vd. (2016). "Clinical experience with systemic cyclosporine A treatment in severe childhood psoriasis". Journal of Dermatological Treatment, 27(4), 328-331.0954-66341471-1753https://doi.org/10.3109/09546634.2015.1115813https://www.tandfonline.com/doi/full/10.3109/09546634.2015.1115813http://hdl.handle.net/11452/29489Background: Severe forms of psoriasis including erythrodermic or pustular psoriasis, which require a more aggressive therapeutic approach such as phototherapy or systemic therapies, are rarely seen. Systemic toxicity and long-term safety of these agents are serious concerns in children. Objective: We report our experience on the efficacy and safety of cyclosporine A treatment in 22 patients of childhood psoriasis. Methods: We retrospectively analyzed the records of all patients less than 18 years of age treated with systemic cyclosporine A therapy at our clinic between January 2000 and March 2009. Demographic features as well as other relevant data including previous therapies, the dosage and duration of cyclosporine A therapy, response to treatment and side effects were retrieved from the patients' records. Results: A total of 22 children were treated with systemic cyclosporine A therapy. Seventeen patients were found to be excellent responders. The mean therapeutic dosage of cyclosporine A was 3.47 +/- 0.62 mg/kg/day. The mean duration of cyclosporine A therapy was 5.68 +/- 3.29 months. The median time to total clearance of the lesions was 4.0 weeks. Conclusion: We conclude that cyclosporine A therapy is equally effective and safe in pediatric psoriasis patients as in adults.eninfo:eu-repo/semantics/closedAccessDermatologyChildhoodCiclosporine ACyclosporine APediatric psoriasisPsoriasisGeneralized pustular psoriasisLow-dose cyclosporineAtopic-dermatitisTransplant recipientsMethotrexateChildrenTherapyMaintenancePatientIndiaAdolescentChildCyclosporineDermatologic agentsFemaleHumansMalePsoriasisRetrospective studiesArticle0003765183000062-s2.0-8494957987032833127426651208DermatologyPustulosis Palmoplantaris; Dermatologists; Diaper RashCyclosporin AMethotrexatePrednisoloneCyclosporinDermatological agentAdolescentArticleChildChildhood psoriasisChildhood psoriasisClinical articleDrug dose reductionDrug efficacyDrug safetyDrug withdrawalEvening dosageFemaleFlu like syndromeHumanHypertensionHypertrichosisMaleMedical recordMonotherapyMorning dosagePriority journalPsoriasisRetrospective studySystemic therapyTreatment durationTreatment responsePsoriasis