Aksit, DilekYalinkilinc, Hande SultanSekkin, SelimBoyacioglu, MuratAyaz, ErolGokbulut, Cengiz2023-10-062023-10-062015-12-12Aksit, D. vd. (2015). "Comparative pharmacokinetics and bioavailability of albendazole sulfoxide in sheep and goats, and dose-dependent plasma disposition in goats". BMC Veterinary Research, 11(1)1746-6148https://doi.org/10.1186/s12917-015-0442-5https://bmcvetres.biomedcentral.com/articles/10.1186/s12917-015-0442-5http://hdl.handle.net/11452/34230Background: The aims of this study were to compare the pharmacokinetics of albendazole sulfoxide (ABZ-SO, ricobendazole) in goats and sheep at a dose of 5 mg/kg bodyweight (BW), after intravenous (IV) and subcutaneous (SC) administrations, and to investigate the effects of increased doses (10 and 15 mg/kg BW) on the plasma disposition of ABZ-SO in goats following SC administration. A total of 16 goats (Capra aegagrus hircus, eight males and eight females) and 8 sheep (Ovis aries, four males and four females) 12-16 months old and weighing 20-32 kg, were used. The study was designed according to two-phase crossover study protocol. In Phase-1, eight sheep were assigned as Group I and 16 goats were allocated into two groups (Group II and Group III). ABZ-SO was applied to Group I (sheep) and Group II (goats) animals subcutaneously, and to Group III (goats) animals intravenously, all at a dose rate of 5 mg/kg BW. In Phase-2, the sheep in the Group I received ABZ-SO intravenously in a dose of 5 mg/kg BW; the goats in Group II and Group III received ABZ-SO subcutaneously at a dose of 10 mg/kg and 15 mg/kg BW, respectively. Blood samples were collected from the jugular vein at different times between 1 and 120 h after drug administrations. The plasma concentrations of ABZ-SO and its metabolites were analysed by high performance liquid chromatography. Results: In goats, the area under the curve, terminal half-life and plasma persistence of ABZ-SO were significantly smaller and shorter, respectively, compared with those observed in sheep following both IV and SC administrations at a dose of 5 mg/kg BW. On the other side, dose-dependent plasma dispositions of ABZ-SO were observed following SC administration at increased doses (10 and 15 mg/kg) in goats. Conclusions: Consequently, ABZ-SO might be used at higher doses to provide higher plasma concentration and thus to achieve greater efficacy against the target parasites.eninfo:eu-repo/semantics/closedAccessVeterinary sciencesBenzimidazolesAlbendazoleAlbendazole sulfoxidePharmacokineticsEnantiomersSheepGoatDairy goatsEnantiomersRicobendazoleMetabolitesFenbendazoleOxfendazoleNetobiminBehaviorPharmacologyFormulationBenzimidazolesSheepAnimaliaCapra hircusOvis ariesAdministration, IntravenousAlbendazoleAnimalsAnthelminticsArea under curveDose-response relationship, DrugFemaleGoatsHalf-lifeInjections, SubcutaneousMaleSheepSpecies specificityArticle0003550777000012-s2.0-8501926329411126012791Veterinary sciencesAlbendazole; Benzimidazole; Anthelmintic agentAlbendazoleAlbendazole sulfoxideAnthelmintic agentAnalogs and derivativesAnimalArea under the curveBloodDose responseFemaleGoatHalf life timeIntravenous drug administrationMaleMetabolismSheepSpecies differenceSubcutaneous drug administration