2021-08-312021-08-312005-07Güllülü, S. vd. (2005). "Tissue Doppler echocardiography and myocardial performance index in patients with scleroderma". Journal of International Medical Research, 33(4), 417-424.0300-06051473-2300https://doi.org/10.1177/147323000503300407https://journals.sagepub.com/doi/10.1177/147323000503300407http://hdl.handle.net/11452/21583In this study, left and right ventricular functions were examined echocardiographically in 22 patients with scleroderma and 22 healthy volunteers. Conventional and tissue Doppler echocardiography and myocardial performance indexes were used as measures of right and left ventricular global functions. Mitral early diastolic E wave deceleration time, isovolumetric contraction time and left ventricular myocardial performance index and peak tricuspid A wave velocity were significantly higher in the scleroderma group compared with the control group. Mitral and tricuspid E/A ratios were significantly lower in patients with scleroderma. In addition, mitral annular and tricuspid annular isovolumetric relaxation times and the tricuspid E/E' ratio were significantly increased in scleroderma patients compared with the control group. In conclusion, in scleroderma patients the global left ventricular functions were depressed and diastolic function abnormalities were seen in both right and left ventricles. In addition, longitudinal muscle functions of the ventricles were depressed in scleroderma patients, as shown by tissue Doppler imaging parameters.eninfo:eu-repo/semantics/closedAccessEchocardiographyTissue Doppler imagingSclerodermaMyocardial performance indexSystemic-sclerosis sclerodermaVentricular diastolic functionPulmonary-hypertensionHeartInvolvementFibrosisVelocityMotionResearch & experimental medicinePharmacology & pharmacyArticle0002309096000072-s2.0-2304444589441742433416104445Medicine, research & experimentalPharmacology & pharmacySystemic Scleroderma; Interstitial Pneumonia; Connective Tissue DiseasesA waveAdultClinical articleClinical trialControlled clinical trialControlled studyDoppler echocardiographyFemaleHeart contractionHeart failureHeart left ventricle enddiastolic pressureHeart left ventricle functionHeart performanceHeart right ventricle functionHumanMaleMitral valveRelaxation timeSclerodermaTricuspid valve