2021-10-082021-10-082002-05-10Özarda, Y. vd. (2002). "The decline in serum choline concentration in humans during and after surgery is associated with the elevation of cortisol, adrenocorticotropic hormone, prolactin and beta-endorphin concentrations". Neuroscience Letters, 324(1), 41-44.0304-3940https://doi.org/10.1016/S0304-3940(02)00171-4https://www.sciencedirect.com/science/article/pii/S0304394002001714http://hdl.handle.net/11452/22289Serum choline concentrations decrease during and after surgery. We undertook this study to determine whether the decrease of choline is associated with an increase in stress hormones. In 16 patients undergoing abdominal surgery with general anesthesia, circulating choline cortisol, prolactin, adrenocorticotropic hormone (ACTH) and beta-endorphin levels were measured before, during and after surgery. Choline levels decreased by 41% (P < 0.01) during surgery, remained 15-38% decreased for 48 h, and returned to preoperative values 72 h after surgery. The decrease in serum choline was associated and inversely correlated with the increase in serum cortisol (P < 0.001; r = -0.642), prolactin (P < 0.001; r = -0.756), beta-endorphin (P < 0.001; r = -0.726) and ACTH (P < 0.01; r = -0.458). In conclusion, we found that abdominal surgery induces a decline in serum choline associated with an increase in circulating cortisol, prolactin, ACTH and beta-endorphin.eninfo:eu-repo/semantics/closedAccessCholineAcetylcholine-releaseStress-responseSurgical stressIncreaseStriatumNeuronsSurgeryStressCortisolProlactinAdrenocorticotropic hormoneBeta-endorphinNeurosciences & neurologyAdrenocorticotropic hormoneAcetylcholineCholineBeta-endorphinDown-regulationFemaleHumansHydrocortisoneMalePostoperative complicationsNeurosecretory systemsProlactinStressSynaptic transmissionUp-regulationArticle0001757930000112-s2.0-00370527294144324111983290Neurosciences & neurologyCholine; Dimethylglycine; BetainesHormone blood levelAbdominal surgeryArticleBlood analysisBlood levelCirculationClinical articleConcentration (Parameters)Controlled studyCorrelation analysisGeneral anesthesiaHormone DeterminationHumanPerioperative periodPostoperative periodPreoperative periodPriority journalStressTime