2021-11-182021-11-182002Karadağ, M. vd. (2002)."Chromosomal fragile sites and relationship between genetic predisposition to small cell lung cancer". Teratogenesis Carcinogenesis and Mutagenesis, 22(1), 31-40.0270-3211https://doi.org/10.1002/tcm.1036https://onlinelibrary.wiley.com/doi/10.1002/tcm.1036http://hdl.handle.net/11452/22722Fragile sites are non-staining gaps and breaks on mammalian chromosomes. Several investigators have pointed out that these sites may act as factors that predispose to specific chromosomal rearrangements that are present in some cancer cases. The expression of common fragile sites induced by aphidicolin (Ape) was evaluated on prometaphase chromosomes obtained from the peripheral blood lymphocytes of 15 patients with lung cancer, 20 of their clinically healthy family members, and 20 age-matched normal controls. As a result of cytogenetic evaluation carried out by the High Resolution Banding (HRB) technique, 1q21, 2q33, 3p14, 7q32, 13q13, 16q23, 17q21, and 22q12 are defined as fragile sites in patients and relatives. The rate of total fragile sites and 2q33, 3p14, and 16q23 are statistically significant in both patients and relatives when compared with the control group. Therefore, our results showed that common fragile sites might be unstable factors in the human genome and they can be used as suitable markers for genetic predisposition to lung cancer.eninfo:eu-repo/semantics/openAccessNonrandom distributionSmall cell lung cancerChromosome aberrationChromosome aberrationCommon fragile sitesGenetic pre-dispositionPeripheric blood lymphocyte culturesBreast-cancershort armExpression frequencyRenal-cellFhit geneHeterozygosityAphidicolinLymphocytesSusceptibilityOncologyGenetics & heredityToxicologyMammaliaCytogeneticsAdolescentAdultAgedCarcinoma, small cellChromosome aberrationsChromosome breakageChromosome fragile sitesChromosome fragilityChromosomes, humanGenetic markersFemaleHumansGenetic predisposition to diseaseLung neoplasmsLymphocytesMaleMiddle agedPedigreeArticle0001729502000032-s2.0-0036135197314022111754385OncologyGenetics & heredityToxicologyWW Domain Containing Oxidoreductase; Spinocerebellar Ataxia 12; Chromosome Fragile SitesChromosome 16qAphidicolinAdultAgedArticleChromosomal localizationChromosome 13qChromosome 3pChromosome 17qChromosome 1qChromosome 22qChromosome 2qChromosome 7qChromosome breakageChromosome fragilityChromosome high resolution banding analysisControlled studyClinical articleCytogeneticsFemaleGene expression regulationGene rearrangementGenetic markerGenetic predispositionGenetic stabilityHumanLung cancerLung small cell cancerMaleMetaphasePeripheral lymphocytePriority journalRelative