Chillemi, ValeriaLo Passo, CarlaVan Diepeningen, Anne D.Rharmitt, SanaeDelfino, DemetrioCascio, AntonioNnadi, Nnaemeka EmmanuelSampaio, PaulaTietz, Hans-JuergenPeman, JavierCriseo, GiuseppeRomeo, OrazioScordino, Fabio2022-12-132022-12-132016-02-15Chillemi, V. vd. (2016). "Multilocus microsatellite analysis of European and African Candida glabrata isolates". European Journal of Clinical Microbiology and Infectious Diseases, 35(6), 885-892.0934-97231435-4373https://doi.org/10.1007/s10096-016-2610-3https://link.springer.com/article/10.1007/s10096-016-2610-3http://hdl.handle.net/11452/29846This study aimed to elucidate the genetic relatedness and epidemiology of 127 clinical and environmental Candida glabrata isolates from Europe and Africa using multilocus microsatellite analysis. Each isolate was first identified using phenotypic and molecular methods and subsequently, six unlinked microsatellite loci were analyzed using automated fluorescent genotyping. Genetic relationships were estimated using the minimum-spanning tree (MStree) method. Microsatellite analyses revealed the existence of 47 different genotypes. The fungal population showed an irregular distribution owing to the over-representation of genetically different infectious haplotypes. The most common genotype was MG-9, which was frequently found in both European and African isolates. In conclusion, the data reported here emphasize the role of specific C. glabrata genotypes in human infections for at least some decades and highlight the widespread distribution of some isolates, which seem to be more able to cause disease than others.eninfo:eu-repo/semantics/openAccessInfectious diseasesMicrobiologyEpidemiologyAfricaAllelesCandida glabrataCandidiasisDNA, fungalEnvironmental microbiologyEuropeGenetic lociGenetic variationGenotypeHaplotypesHumansMicrosatellite repeatsMultilocus sequence typingArticle0003770220000012-s2.0-8496010296388589235626946511Infectious diseasesMicrobiologyCandida Glabrata; Adhesins; FluconazoleFungal DNAMicrosatellite DNAAfricanArticleCandida glabrataEuropeanFungus isolationGenetic variabilityGenotypeHaplotypeMicrobiological examinationMicrosatellite markerMolecular phylogenyMultilocus microsatellite analysisNonhumanPhenotypePriority journalAfricaAlleleCandida glabrataCandidiasisClassificationEuropeGene locusGenetic variationGeneticsHumanIsolation and purificationMicrobiologyMultilocus sequence typing