2022-10-242022-10-242006-12-19Köseler, A. vd. (2007). "Frequency of mutated allele CYP2D6*4 in the Turkish population". Pharmacology, 79(4), 203-206.0031-7012https://doi.org/10.1159/000100959https://www.karger.com/Article/Abstract/100959http://hdl.handle.net/11452/29195The frequency of functionally important mutations and alleles of the gene coding for CYP2D6 shows wide ethnic variations. The present study aimed to determine the most common mutated allele CYP2D6*4 gene in a Turkish population of 100 unrelated subjects, by using real-time PCR with fluorescent probe. CYP2D6*4 allele was not detected in 62 subjects ( 62%). Among the remaining 38 subjects (38%), 4 (4%) were carriers of two *4 alleles, being homozygous for CYP2D6 and genotyped as CYP2D6*4/*4.34 subjects (34%) were carriers of one *4 allele, being heterozygous for CYP2D6*4. The frequency of allele *4 was 0.21. These data indicate that 4% of the Turkish individuals living in the city of Bursa are carriers of two nonfunctional mutated alleles *4, being homozygous for CYP2D6*4. It is clinically important to be able to identify those individuals who are likely to have altered pharmacokinetics for CYP2D6 substrates in order to avoid adverse drug reactions.eninfo:eu-repo/semantics/closedAccessCYP2D6PolymorphismReal-time PCRHydroxylation polymorphismsCytochrome-P450 enzymesGenetic polymorphismsRussian populationSwedish populationCyp2c19 genotypesCyp2d6 genesDebrisoquineChinese2d6TurkeyCytochrome P-450 CYP2D6Gene frequencyGenetics, populationHumansPolymorphism, geneticReverse transcriptase polymerase Chain ReactionArticle0002470286000022-s2.0-3424982079420320679417374963Pharmacology & pharmacyCytochrome P-450 CYP2D6; Pharmacogenomics; RacemorphanHomozygoteCytochrome P450 2D6Fluorescent dyeAlleleArticleControlled studyFluorescenceGene frequencyGene identificationGene mutationGenotypeHeterozygoteHumanPriority journalReverse transcription polymerase chain reactionTurkey (republic)Normal human