2024-03-052024-03-052018-03Aydın, M. vd. (2018). ''Rapid emergence of colistin resistance and its impact on fatality among healthcare-associated infections''. Journal of Hospital Infection, 98(3), 260-263.0195-67011532-2939https://www.sciencedirect.com/science/article/pii/S0195670117306412https://hdl.handle.net/11452/40219Çalışmada 31 yazar bulunmaktadır. Bu yazarlardan sadece Bursa Uludağ Üniversitesi mensuplarının girişleri yapılmıştırThis article describes the emergence of resistance and predictors of fatality for 1556 cases of healthcare-associated Gram-negative bloodstream infection in 2014 and 2015. The colistin resistance rate in Klebsiella pneumoniae was 16.1%, compared with 6% in 2013. In total, 660 (42.4%) cases were fatal. The highest fatality rate was among patients with Acinetobacter baumannii bacteraemia (58%), followed by Pseudomonas aeruginosa (45%), Klebsiella pneumoniae (41%), Enterobacter cloacae (32%) and Escherichia coli (28%). On multi-variate analysis, the minimum inhibitory concentrations for carbapenems [odds ratio (OR) 1.02, 95% confidence interval (CI) 1.01-1.04; P = 0.002] and colistin (OR 1.1, 95% CI 1.03-1.17; P = 0.001) were found to be significantly associated with fatality.eninfo:eu-repo/semantics/closedAccessPublic, environmental & occupational healthInfectious diseasesBloodstreamGram-negativeHealth careColistin MICAdultAgedAged, 80 and overAnti-bacterial agentsBacteremiaCarbapenemsColistinCross infectionFemaleGram-negative bacteriaGram-negative bacterial infectionsHumansMaleMicrobial sensitivity testsMiddle agedRetrospective studiesArticle0004263167000112-s2.0-8504436395526026398329248504https://doi.org/10.1016/j.jhin.2017.11.014Public, environmental & occupational healthInfectious diseasesColistin; Escherichia Coli; Resistance GenesCarbapenem derivativeColistinAntiinfective agentCarbapenem derivativeColistinAcinetobacter baumanniiAdultAntibiotic resistanceArticleBacteremiaBloodstream infectionDrug effectEnterobacter cloacaeEscherichia coliFatalityFemaleHealthcare associated infectionHumanKlebsiella pneumoniaeMajor clinical studyMaleMinimum inhibitory concentrationMortality ratePseudomonas aeruginosaRetrospective studyAgedClinical trialCross infectionGram negative bacteriumGram negative infectionIsolation and purificationMicrobial sensitivity testMicrobiologyMiddle agedMortalityMulticenter studyVery elderly