Karkucak, Mutlu2022-04-112022-04-112012-10Karkucak, M. vd. (2012). "Analysis of TNF-alpha G308A and C857T gene polymorphisms in Turkish patients with obstructive sleep apnea syndrome". Türkiye Klinikleri Tıp Bilimleri Dergisi, 32(5), 1368-1373.1300-0292https://doi.org/10.5336/medsci.2012-28126https://www.turkiyeklinikleri.com/article/en-analysis-of-tnf-alpha-g308a-and-c857t-gene-polymorphisms-in-turkish-patients-with-obstructive-sleep-apnea-syndrome-63032.htmlhttp://hdl.handle.net/11452/25696Objective: Tumor necrosis factor-alpha (TNF-alpha) is an important indicator of inflammation. Recent studies have demonstrated a relationship between inflammation and obstructive sleep apnea syndrome (OSAS). The aim of this study was to investigate the association between TNF-alpha G308A and C857T gene polymorphisms and OSAS in Turkish patients. Material and Methods: Sixty-nine patients who were diagnosed with OSAS and 42 control subjects were included in the study. The polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was used to detect TNF-alpha G308A and C857T gene polymorphisms. The level of significance for statistical analysis was set at p<0.05. Results: The distribution of genotypes was not significantly different between subjects with a definite diagnosis of OSAS and the control group (p> 0.05). However, the mean body mass index of the OSAS group was significantly different from that of the control group (p<0.05). Conclusion: To our knowledge, this study is the first to analyze the relationship between OSAS and INF-alpha G308A and C857T gene polymorphisms in Turkish patients. Our results do not support an association between OSAS and TNF-alpha G308A and C857T gene polymorphisms.eninfo:eu-repo/semantics/openAccessGeneral & internal medicinePolymorphism, single nucleotideSleep apnea, obstructiveAngiotensin-converting enzymeCardiovascular-diseasePromoter polymorphismAssociationCytokinesObesityArthritisAllelesRegionArticle0003133783000232-s2.0-8486386549813681373325Medicine, general & internalObstructive Sleep Apnea; Polysomnography; SnoringTumor necrosis factor alphaAdultApnea hypopnea indexArticleBody massControlled studyFemaleGeneGene frequencyGenetic associationGenetic polymorphismGenetic variabilityGenome analysisHumanMajor clinical studyMaleMolecular weightPolymerase chain reactionRestriction fragment length polymorphismSleep apnea syndromeTumor necrosis factor alpha gene