2021-10-232021-10-232002-07Özarda, Y. vd. (2002). "Free choline and phospholipid-bound choline concentrations in serum and dialysate during peritoneal dialysis in children and adults". Clinical Biochemistry, 35(4), 307-313.0009-9120https://doi.org/10.1016/S0009-9120(02)00319-3https://www.sciencedirect.com/science/article/pii/S0009912002003193http://hdl.handle.net/11452/22452Objectives: This study tested whether continuous ambulatory peritoneal dialysis (CAPD) changes free or phospholipid-bound choline concentrations in serum or peritoneal dialysis fluid of patients with end stage renal disease (ESRD). Design and methods: Serum and dialysate choline and phospholipid-bound choline were measured before, during and after 6 h CAPD. Results: Serum choline concentrations were higher in patients with ESRD compared with age-matched controls. CAPD lowered serum choline concentrations significantly although it did not influence phospholipid-bound choline. Choline accumulated in the dialysate, reaching 28.4 +/- 2.7 muM in children and 18.2 +/- 1.4 muM in adults, during six hours CAPD; phospholipid-bound choline increased to 22.9 +/- 2.5 muM and 10.8 +/- 1.4 muM in children and adults, respectively. The total daily loss of choline into the dialysate was 181 +/- 20 mumoles in children and 260 +/- 18 mumoles in adults. Conclusion: CAPD causes a substantial loss of choline into peritoneal dialysates and reduces serum choline concentrations significantly.eninfo:eu-repo/semantics/closedAccessCholinePhospholipid-bound cholineEnd stage renal diseaseCAPDPeritoneal dialysisRat corpus striatumAcetylcholine-releaseParenteral-nutritionTyrosine-HydroxylasePlasma cholineBrainMetabolismDeficiencyTransportCytidineLiverMedical laboratory technologyChildAdolescentAdultAgedPhospholipidsCholineCholine deficiencyColorimetryDialysis solutionsFemaleHumanKidney failure, chronicMaleMiddle agePeritoneal dialysis, continuous ambulatorySupport, non-U.S. gov'tArticle0001773558000102-s2.0-003599261430731335412135694Medical laboratory technologyCholine; Dimethylglycine; BetainesPhospholipidCholinePeritoneal dialysis fluidPhospholipidDialysis fluidAdolescentAdultAgedArticleBlood levelDialysateClinical articleContinuous ambulatory peritoneal dialysisControlled studyFemaleHemodialysis patientHumanKidney diseaseMalePriority journalSchool childTreatment outcomeBloodChildChronic kidney failureColorimetryContinuous ambulatory peritoneal dialysisMetabolismMethodologyMiddle agedVitamin deficiency