Atukeren, PınarKunbaz, AhmadTürk, OkanKemerdere, RahsanUlu, Mustafa OnurTanrıverdi, Taner2022-12-132022-12-132016-06-30Atukeren, P. vd. (2016). "Expressions of endocan in patients with meningiomas and gliomas". ed. Lance A. L. Disease Markers, 2016.0278-02401875-8630https://doi.org/10.1155/2016/7157039https://www.hindawi.com/journals/dm/2016/7157039/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4978841/http://hdl.handle.net/11452/29860Objective. Endocan has been shown to be a marker for several cancers and may show degree of malignancy. The aim of this study is to assess tissue levels of endocan in common brain tumors, namely, meningiomas, low-grade gliomas (LGGs), and high-grade gliomas (HGGs). Patients and Methods. Endocan was assayed by commercially available enzyme linked immunosorbent assay (ELISA) kits in a total of 50 brain tumors (20 meningiomas, 19 LGGs, and 20 HGGs) and 15 controls. The results were compared to control brain tissues. Results. Each tumor group showed significant higher levels of endocan compared to controls (p < 0.05). In addition, endocan levels showed steady increase from the least (meningiomas) to the most (HGGs) malignant tumors and positive correlation was noted between the degree of malignancy and endocan level (p = 0.0001). Conclusion. Endocan, a vital molecule for angiogenesis, is expressed in common brain tumors and results suggest that endocan could be a marker for malignancy.eninfo:eu-repo/semantics/openAccessBiotechnology & applied microbiologyGenetics & heredityResearch & experimental medicinePathologyCell-specific molecule-1MarkerEsm-1SurvivalInvasionCancerAdultBiomarkers, tumorCase-control studiesBrain neoplasmsEnzyme-linked immunosorbent assayFemaleFollow-up studiesGliomaHumansMaleMeningeal neoplasmsMeningiomaNeoplasm proteinsNeoplasm stagingPrognosisProteoglycansArticle0003811305000012-s2.0-84982153572201627528791Biotechnology & applied microbiologyGenetics & heredityMedicine, research & experimentalPathologyDermatan Sulfate Proteoglycan; Human ESM1 Protein; ProteoglycanAnticonvulsive agentEndocanProteinUnclassified drugESM1 protein, humanProteoglycanTumor markerTumor proteinAdultArticleCancer chemotherapyCancer radiotherapyClinical articleComparative studyControlled studyEnzyme linked immunosorbent assayFollow upGliomaHumanHuman tissueMeningiomaNuclear magnetic resonance imagingOverall survivalProtein determinationProtein expressionSeizureSurvival timeBrain tumorCancer stagingCase control studyFemaleGliomaMaleMeningiomaMetabolismPathologyPrognosis