Marzloff, GeorgeSakamoto, ToshimasaWurtman, Richard J.2021-11-292021-11-292009-04Cansev, M. vd. (2009). "Giving uridine and/or docosahexaenoic acid orally to rat dams during gestation and nursing increases synaptic elements in brains of weanling pups". Developmental Neuroscience, 31(3), 181-192.03785866https://doi.org/10.1159/000193394https://www.karger.com/Article/Abstract/193394http://hdl.handle.net/11452/22851Developing neurons synthesize substantial quantities of membrane phospholipids in producing new synapses. We investigated the effects of maternal uridine (as uridine-5′-monophosphate) and docosahexaenoic acid supplementation on pups' brain phospholipids, synaptic proteins and dendritic spine densities. Dams consumed neither, 1 or both compounds for 10 days before parturition and 20 days while nursing. By day 21, brains of weanlings receiving both exhibited significant increases in membrane phosphatides, various pre- and postsynaptic proteins (synapsin-1, mGluR1, PSD-95), and in hippocampal dendritic spine densities. Administering these phosphatide precursors to lactating mothers or infants could be useful for treating developmental disorders characterized by deficient synapses.eninfo:eu-repo/semantics/closedAccessDendritic spinesDevelopmentDocosahexaenoic acidInfant nutritionMembrane phosphatidesSynaptic proteinsSynaptogenesisUridinePolyunsaturated fatty-acidsNucleoside transporter familyCdp-cholineArachidonic-acidDendritic spinesBreast-milkPheochromocytoma cellsNeurite outgrowthFetal-developmentDietary cholineDevelopmental biologyNeurosciences & neurologyAdministration, oralAnimalsAnimals, newbornBlotting, westernBrainBrain chemistryDendritesDietary supplementsDocosahexaenoic acidsFemalePhospholipidsPregnancyRatsRats, sprague-dawleySynapsesUridineArticle0002658625000022-s2.0-6764911116618119231319145070Developmental biologyNeurosciencesCholine Phosphate Cytidylyltransferase; Phosphatidylcholines; CiticolineDocosahexaenoic acidPhospholipidPostsynaptic density protein 95Synapsin IUridine phosphateAnimal experimentAnimal tissueArticleBirthBrainBrain developmentBreast feedingControlled studyDendritic spineDrug effectDrug mechanismFemaleFetusHippocampusLactationMaternal nutritionNewbornNonhumanPregnancyPriority journalRatSupplementationSynapse