2022-09-122022-09-122007-09Ursavaş, A. vd. (2007). "Low level of IGF-1 in obesity may be related to obstructive sleep apnea syndrome". Lung, 185(5), 309-314.0341-20401432-1750https://doi.org/10.1007/s00408-007-9026-xhttps://link.springer.com/article/10.1007%2Fs00408-007-9026-xhttp://hdl.handle.net/11452/28638The aim of this study was to compare serum insulin-like growth factor (IGF-1) levels in patients with obstructive sleep apnea syndrome (OSAS) with those of nonapneic controls and to determine the risk factors of low IGF-1 levels in patients with OSAS. The study included 39 newly diagnosed moderate-to-severe OSAS patients and 36 nonapneic controls. Overnight polysomnography (PSG) was performed in all patients. The circulating levels of IGF-1 in the OSAS group were significantly lower than those of the control group (p < 0.05). There was a significant negative correlation between IGF-1 and logarithmic transformation (Ln) of the apnea-hypopnea index (AHI), duration of apnea-hypopnea, arousal index, average desaturation, and oxygen desaturation index (ODI). The result of stepwise regression analyses showed that OSAS (p = 0.001) was a risk factor for a low IGF-1 level, independent of age, gender, and body mass index (BMI). Our findings demonstrated that there was a significant negative correlation between IGF-1 and Ln AHI and that OSAS reduced the circulating levels of IGF-1.eninfo:eu-repo/semantics/closedAccessInsulin-like growth factorGrowth-factor-iRespiratory systemObesitySleep apneaCoronary-artery diseaseHormone secretionSomatomedin-cHeart-diseaseSerum-levelsBody-massInsulinAssociationGenderDown-regulationAdultCardiovascular diseasesCase-control studiesFemaleHumansInsulin-like growth factor IMaleRisk factorsMiddle agedObesityPolysomnographySeverity of illness indexSleep apnea, obstructiveArticle0002494590000112-s2.0-34548577002309314185517721831Respiratory systemObstructive Sleep Apnea; Positive End Expiratory Pressure; PolysomnographyFemaleOxygenSomatomedin CAdultApneaArousalArticleBody massControlled studyCorrelational studyFatty acid desaturationHumanOxygen saturationInsulin blood levelMajor clinical studyMaleObesityRegression analysisPolysomnographyPriority journalRisk factorSleep apnea syndrome