2021-09-062021-09-062006Hakyemez, B. vd. (2006). ''Meningiomas with conventional MRI findings resembling intraaxial tumors: can perfusion-weighted MRI be helpful in differentiation?''. Neuroradiology, 48(10), 695-702.0028-3940https://doi.org/10.1007/s00234-006-0115-yhttps://link.springer.com/article/10.1007%2Fs00234-006-0115-yhttp://hdl.handle.net/11452/21683Introduction To investigate the contribution of perfusion-weighted MRI to the differentiation of meningiomas with atypical conventional MRI findings from intraaxial tumors. Methods We retrospectively analyzed 54 meningiomas, 12 glioblastomas and 13 solitary metastases. We detected 6 meningiomas with atypical features on conventional MRI resembling intraaxial tumors. The regional cerebral blood flow (rCBV) ratios of all tumors were calculated via perfusion-weighted MRI. The signal intensity-time curves were plotted and three different curve patterns were observed. The type 1 curve resembled normal brain parenchyma or the postenhancement part was minimally below the baseline, the type 2 curve was similar to the type 1 curve but with the postenhancement part above the baseline, and the type 3 curve had the postenhancement part below the baseline accompanied by widening of the curve. Student's t-test was used for statistical analysis. Results On CBV images meningiomas were hypervascular and the mean rCBV ratio was 10.58 +/- 2.00. For glioblastomas and metastatic lesions, the rCBV ratios were 5.02 +/- 1.40 and 4.68 +/- 1.54, respectively. There was a statistically significant difference in rCBV ratios between meningiomas and glioblastomas and metastases (P < 0.001). Only one of the meningiomas displayed a type 2 curve while five showed a type 3 curve. Glioblastomas and metastases displayed either a type 1 or a type 2 curve. None of the meningiomas showed a type 1 curve and none of the glioblastomas or metastases showed a type 3 curve. Conclusion Differentiating meningiomas with atypical conventional MRI findings from malignant intraaxial tumors can be difficult. Calculation of rCBV ratios and construction of signal intensity-time curves may contribute to the differentiation of meningiomas from intraaxial tumors.eninfo:eu-repo/semantics/closedAccessNeurosciences & neurologyRadiology, nuclear medicine & medical imagingPerfusion imagingMeningiomaMagnetic resonanceBrain tumorsMapsGliomasBrainContrastGradient-echoCystic meningiomasMalignant meningiomasCerebral blood-volumeArticle0002409822000012-s2.0-33749344535695702481016896907Clinical neurologyNeuroimagingRadiology, nuclear medicine & medical imagingCerebral Blood Volume; N Acetylaspartic Acid; Glioblastoma