2021-12-022021-12-022009-04Çelikler, S. vd. (2009). "Evaluation of anti-oxidative, genotoxic and antigenotoxic potency of codium tomentosum stackhouse ethanolic extract in human lymphocytes in vitro". Food and Chemical Toxicology, 47(4), 796-801.0278-6915https://doi.org/10.1016/j.fct.2009.01.010https://www.sciencedirect.com/science/article/pii/S0278691509000180http://hdl.handle.net/11452/22967The genome is constantly exposed to agents, both exogenous and endogenous, that damage DNA. Consequently, it is very important that determination of this agents and the protective agents. In this work, we evaluated the antigenotoxic/antimutagenic activity of the crude ethanolic extracts of Codium tomentosurn Stackhouse (Chlorophyceae) (CTE), collected from The Coast of South East Marmara Sea, in human lymphocytes culture in vitro against genotoxic/mutagenic agents MMC, EMS and H2O2 by using chromosome aberration (CA), sister chromatid exchange (SCE) and micronuclei (MN) assays as experimental endpoints. Also, in the present study, we determined total phenolic content and total antioxidant capacity (in soluble lipid and water). In addition, total protein, total carbohydrate, vitamins (A. C and E) and pigments (chlorophyll a, chlorophyll b and carotene) contents were also determined. Results of CA, SCE and MN tests show that CTEs have not shown genotoxic effect. In CTE plus MMC-. EMS- or H2O2- treated cultures, CA, SCE and MN frequency which induced by MMC, EMS or H2O2 has been decreased significantly (p < 0.05-0.001). This is the first report on genotoxicity/antigenotoxicity and anti-oxidative capacity of Codium tomentosum. Our results have clearly shown that CTE has strong anti-oxidative and antigenotoxic effect.eninfo:eu-repo/semantics/closedAccessAnti-oxidative effectCACodium tomentosumMNOxidative and chromosome damageSCEAntiproliferative activitiesAntibacterial activityMarine-algaeRed algaDietarySeaweedDnaMicronucleiInductionProductsFood science & technologyToxicologyChlorophyceaeCodium tomentosumAdolescentAdultAlgae, greenAntimutagenic agentsAntioxidantsChromosome aberrationsDNA damageFemaleHumansLymphocytesMaleMutagensSister chromatid exchangeArticle0002646230000192-s2.0-6084909606979680147419167449Food science & technologyToxicologySeaweeds; Padina; UlvaAlpha tocopherolAscorbic acidCarbohydrateCaroteneChlorophyll aChlorophyll bCodium tomentosum stackhouse extractHydrogen peroxideLipidMesylic acid ethyl esterMitomycin CPhenolPlant extractRetinolUnclassified drugWaterAdultAntioxidant activityArticleCell levelChlorophyll contentChromosome aberrationCodium tomentosum StackhouseControlled studyDrug effectDrug isolationDrug potencyDrug screeningFemaleGenotoxicityHumanHuman cellIn vitro studyLymphocyteLymphocyte cultureMaleMicronucleus testNormal humanProtein contentSeaweedSister chromatid exchange