Knowles, W. D.Özmen, Tolga2021-07-122021-07-121989Korfalı, E. vd. (1989). ''Fetal substantia nigra grafts-effect on dopamine receptors in the rat corpus striatium''. Cleveland Clinic Journal of Medicine, 56(3), 259-262.0891-1150https://doi.org/10.3949/ccjm.56.3.259https://pubmed.ncbi.nlm.nih.gov/2568188/http://hdl.handle.net/11452/21221Effects of fetal substantia nigra grafts on the dopamine receptors in the corpus striatum in rats were investigated after the destruction of the nigrostriatal dopaminergic pathways with intraventricular 6-hydroxydopamine injections. The expected dopamine receptor denervation supersensitivity was demonstrated by a 53.7% increase of [3H]spiroperidol binding in rats with sham grafts compared with normal control-group rats. In contrast, rats with grafts showed a significant reduction of supersensitivity, with a 25% decrease in binding to the graft-bearing caudate when compared with the sham-graft group. A nonsignificant 15% decrease in binding on the nongrafted side was also observed. The fetal substantia nigra grafts thus reduced the denervation supersensitivity toward a normal level.eninfo:eu-repo/semantics/openAccessGeneral & internal medicineSubstantia nigraAnimal experimentArticleBrain graftCorpus striatumFetusatNonhumanRatNonhumanArticleA1989U8301000082-s2.0-00249349542592625632568188Medicine, general & internal