19 Uludag Univ. J. Fac. Vet. Med. 25 (2006), 1-2: 19-21 Vulvo-Vaginal Atresia in a Queen With Mammary and Uterine Tumors: Case Report Güneş SERİN* Mehmet Erkut KARA** İlker SERİN* Geliş Tarihi: 30.11.2006 Kabul Tarihi: 16.02.2006 Abstract: The clinical, preoperative and postoperative findings taken from a case of vulvovaginal atresia in a queen with mammary tumors are reported here. The catheterization of the vulva showed only two small openings in dorsal and ventral comissura regions. During the ultrasonographic examination, uterine masses were observed. For treatment of mammary and uterine tumors, radical mastectomy and ovariohysterectomy were performed. In histopathological examination, mammary tumors and concurrent uterine mass were papillary adeocarcinoma and endometrial polyp, respectively. In this case nulliparity cause of vulval anomaly might be a predisposing factor for mammary and concurrent uterine tumors. Key Words: Congenital anomalies, vulvovaginal atresia, cat. Meme ve Uterus Tümörü Bulunan Bir Kedide Vulvo-Vaginal Atresi Olgusu Özet: Bu sunumda meme tümörlü bir kedideki vulvovaginal atresi olgusunun klinik, preoperatif ve postoperatif bulguları verilmiştir. Vulvanın kateterizasyonunda dorsal ve ventral komissurasında olmak üzere iki küçük açık- lık olduğu görüldü. Uterusun ultrasonografik muayenesinde ise kitlelere rastladı. Meme ve uterusdaki kitlelerin tedavisi için radikal mastektomi ve ovaryohisterektomi operasyonları uygulandı. Histopatolojik incelemede memede papillar adenokarsinoma, uterusda ise endometriyal poliplerin varlığı belirlendi. Bu hastada vulval anomaliye bağlı nulliparite olgusunun meme tümörü ve eş zamanlı endometrial poliplerin oluşumu için predizpoze faktör olabileceği düşünülmektedir. Anahtar Sözcükler: Kongenital anomali, vulvovaginal atresi, kedi. Introduction masses under ultrasonography (GELBERG and McENTEE., 1984). Congenital abnormalities of the reproduc- Although congenital abnormalities and tive tract are rare in the queen. Vulval and vagi- neoplasia of the reproductive tract are seldom, nal atresia may occur separately or simultane- mammary tumors are known to be frequently ously. Small labia with or without stenosis of the occuring in the cat. These tumors usually are vestibule are observed in the former, whilst malignant carcinomas (%80-90) (JOHNSTON et stenosis of the vagina is observed in the latter al., 2001). (SAPERSTEIN et al., 1976). Noakes et al. re- ported that vaginal abnormalities may cause Case History endometrial changes. Also uterine tumors are observed rarely in the cat. Endometrial polyps An adult mixed breed stray cat weighing which are beningn uterine tumors are 2.5 kg was presented to Gynecology Clinic of characterised by focal, cystic proliferations of the Faculty of Veterinary Medicine at the Adnan the endometrial glands. When they invade the Menderes University, with the complaint of uterine lumen, they appear as multi-lobular three mammary masses on the right gland chain ∗ DVM PhD Adnan Menderes University, Faculty of Veterinary Medicine, Department of Obstetrics and Reproductive Diseases, 09016, Aydın / TURKEY ∗∗ DVM PhD Adnan Menderes University, Faculty of Veterinary Medicine, Department of Anatomy, 09016 Aydın / TURKEY 20 and also one of them was ulcerated. Her body In treatment, firstly all glands on the right condition and appetite were normal. In the ra- side were removed in radical mastectomy. The diographic examination, no pulmonary metasta- diameters of tumors which were measured ex- ses on ventrodorsal radiographs of the thorax ternally with the aid of micrometric calliper were could be detected. However, a mass of 2 cm 3.1×4.5, 1.9×2.7, 2.4×3.1 cm (Figure 2). Sec- diameter in right uterine horn was seen from the ondly, ovariohysterectomy was performed for abdominal ultrasonographic examination. Blood uterine masses. Vulvo and/or vaginoplasty were analyses were normal except white blood cell not performed due to having no problem in uri- (WBC) count was 360 X 102/µl. nation and also it is being spayed. On genital examination, it was seen that the labia vulva were small and fused, allowing Results and Discussion two small openings with 2.6 mm and 1 mm in diameter in dorsal and ventral commissura re- Postoperatively, antibacterial therapy was gions, respectively (Figure 1-B). The catheteri- applied with 8.75 mg/kg amoxycillin - clavu- zation of larger dorsal opening (with a cat uri- lanic acid (Synulox®; Pfizer) daily for five days. nary catheter, 1x130 mm, Kruuse) was permitted Urination was normal and her WBC count de- to insert in 20 mm from vulva and the connec- creased gradually in five days. According to a tion of the external urethral orifice was also de- report from the Department of Pathology, Adnan termined. On the other hand, the small ventral Menderes University, on 08/07/2004, protocol opening could not be catheterized (blind ended). number 82/04, histopathological examination of The soluble iodine contrast medium (sodium diatrizoate 100 mg/ml, meglumine diatrizoate the mammary gland is papillary adenocarcinoma 660 mg/ml, Urografin®; Schering) via the dorsal and uterine mass which was detected opening was given for the examination of the concurrently are proliferative polyps in the cavities of vagina and vestibule in contrast- endometrium (Figure 2). radiographic examination (Figure 1-A). The vaginal discharge, perivulvar dermatitis, pruritis and urinary incompetence were not observed during hospitalization. Figure 2. Appearance of the uterine (u) and mammary tumors of inguinal (ig), thoracic (tg) and ab- dominal (ag) glands. Figure 1. Resim 2. Contrast-radiograph atretic vagina (A). Uterus ve meme tümörlerinin görünümü. İnguinal Catheter could be inserting about 20 mm from (ig), torasik (tg) ve abdominal (ab) meme lobları. dorsal opening to vagina, v-1: Larger dorsal opening of vulva, av: atretic vagina (short and In this case, the only larger opening con- narrow), us: urogenital sinus. tinued cranially and provided for urination. It The view of vulva (B). Arrows show opennings of seemed that neither dorsal nor the ventral open- the vulva, dorsally and ventrally. ings are suitable for copulation. This is consid- Resim 1. ered to be resulted from the embriyonic insuffi- Atretik vaginanın contrast-radyogafisi (A). Kateter ciency of the canalization of the parameso- vaginanın dorsal girişinden yaklaşık 20 mm kadar içeri uygulandı. v-1: Vulvanın büyük dorsal açıklı- nephronic duct between the end of the Müllerian ğı, av: atretik vagina (kısa ve dar yapıda), us: duct and the urogenital sinus (BLOOM, 1954). urogenital sinus. Vaginal atresia with transverse septum Vulvanın görünümü (B). Vulvanın dorsal ve (NOMURA et al., 1997) and vaginal aplasia vaginal açıklığı oklarla gösterilmiştir (BAINES et al., 1999) are recorded in cat. Al- though, similar case could not be reported in cat. 21 Endometrial polyps are reported in do- 4. GELBERG HB, McENTEE K. Hyperplastic en- mestic queen (GELBERG and McENTEE., dometrial polyps in the dog and cat. Vet. Pathol., 1984), and increase due to nulliparity in ele- 1984; 21: 570-3. phants (AGNEW et al., 2004), and women 5. JOHNSTON SD, KUSTIRTZ MGV, OLSON PN. (RESLOVA et al., 1999). Also mammary tumors Disorders of the mammary glands of the queen. incidence increases in intact female cats In: Johnston, S.D. Ed. Canine and Feline Therio- (JOHNSTON et al., 2001). genology. Philadelphia, W. B. Saunders, 477; 2001. Consequently, nulliparity related to vulval anomaly may be accepted as a predisposing fac- 6. NOAKES DE, PARKINSON TJ, ENGLAND GCW. 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