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Title: Effect of misoprostol on acute cisplatin nephrotoxicity
Authors: Antypas, G.
Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Biyoloji Anabilim Dalı.
Kurt, Ender
Manavoğlu, Osman
Dilek, Kamil
Orhan, Bulent
Evrensel, Türkkan
Keywords: Oncology
Prostaglandin-e1 analog misoprostol
Cyclosporine nephrotoxicity
Oral misoprostol
Indomethacin Cells
Issue Date: 1999
Publisher: Medimond S R L
Citation: Kurt, E. vd. (1999). "Effect of misoprostol on acute cisplatin nephrotoxicity". ed. G Antypas. 2nd Balkan Congress of Oncology, 401-406.
Abstract: Protective effects of misoprostol on non steroidal antiinflammatory drugs (NSAIDs) and cyclosporine nephrotoxicity is well described in the literature, but the role of misoprostol in cisplatin nephrotoxicity is not fully understood. In our study, we planned to investigate the protective effect of misoprostol in acute cisplatin nephrotoxicity. Our patient group consisted 28 patient with lung cancer. All patients received cisplatin + etoposide chemotherapy regimen. The patients were divided into two groups. Misoprostol Group (14 patients); was given misoprostol 100 mu g qid (po) during chemotherapy. Control Group (14 patients); only received chemotherapy. Glomerular and proximal tubular functions were measured in both groups before the onset of chemotherapy and on the 2(nd) and 6(th) days of chemotherapy. As a result of our study, we have not been able to show the protective effect of misoprostol in tubular and glomerular functional disturbances due to cisplatin administration.
Description: Bu çalışma, 10-14 Eylül 1998 tarihleri arasında İzmir[Türkiye]'de düzenlenen 2nd Congress of the Balkan-Union-of-Oncology'de bildiri olarak sunulmuştur.
ISBN: 88-323-0910-6
Appears in Collections:Web of Science

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