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|Title:||Adiponectin and IGF-1 are negative acute phase proteins in a dog model of acute endotoxaemia|
Ceron, Jose J.
Uludağ Üniversitesi/Veterinerlik Fakültesi/Dahiliye Anabilim Dalı.
Eralp, Oya İnan
|Citation:||Tvarijonaviciute, A. vd. (2011). "Adiponectin and IGF-1 are negative acute phase proteins in a dog model of acute endotoxaemia". Veterinary Immunology and Immunopathology, 140(1-2), 147-151.|
|Abstract:||The objective of this study was to evaluate the influence of an experimentally induced acute inflammation on serum adiponectin and insulin-like growth factor 1 (IGF-1) levels in the dog, and to compare their evolution with other well-established acute phase proteins (APPs) such as C-reactive protein (CRP), and haptoglobin (Hp). Therefore levels of adiponectin, IGF-1 and a profile of APPs were measured in healthy dogs after intravenous administration of E. coli LPS (0.02 mg/kg) and compared with dogs injected with saline solution (0.2 mL/kg). Adiponectin and IGF-1 were both decreased in response to endotoxins in the dog. Significant positive correlations were found between adiponectin and IGF-1 (r = 0.31; p < 0.05). Adiponectin had also a significant negative correlation with CRP (r = 0.39; p < 0.05) and Hp (r = -0.27; p < 0.05), whereas IGF-1 had significant negative correlation with CRP (r = -0.52; p < 0.001). The results obtained in the present study indicate that adiponectin and IGF-1 behave as negative acute phase proteins after acute inflammatory stimulus in dogs.|
|Appears in Collections:||Scopus|
Web of Science
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