Please use this identifier to cite or link to this item:
|Title:||Anti-cancer activity of a novel palladium(II) complex on human breast cancer cells in vitro and in vivo|
İkitimur, Elif İlkay
Uludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.
Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Biyoloji Bölümü.
Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Kimya Bölümü.
Yılmaz, Veysel T.
|Keywords:||Pharmacology & pharmacy|
|Citation:||Ulukaya, E. vd. (2011). “Anti-cancer activity of a novel palladium(II) complex on human breast cancer cells in vitro and in vivo”. European Journal of Medicinal Chemistry, 46(10), 4957-4963.|
|Abstract:||Anti-cancer effects of a newly-synthesized palladium(II) complex, [Pd(sac)(terpy)](sac)center dot 4H(2)O (sac = saccharinate, and terpy = 2,2':6',2 ''-terpyridine), were tested against human breast cancer cell lines, MCF-7 and MDA-MB-231. The Pd complex had a strong anti-growth effect in a dose- and time-dependent manner in vitro. This effect was also confirmed by the experiment performed on Balb/c mice in vivo. The IC50 values were 0.09 mu M for MDA-MB-231 and 3.05 mu M for MCF-7. It was also very effective in disrupting the formation of MDA-MB-231 tubules on matrigel, indicative of a putative anti-invasive activity. It induced apoptosis via the cell death genes of DR4 and DR5. In conclusion, this newly-synthesized Pd (II) complex represents a potentially active novel drug for the breast cancer treatment.|
|Appears in Collections:||Scopus|
Web of Science
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.