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|Title:||Free choline and phospholipid-bound choline concentrations in serum and dialysate during peritoneal dialysis in children and adults|
|Authors:||Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı.|
Uludağ Üniversitesi/Tıp Fakültesi/Farmakoloji ve Klinik Farmakoloji Anabilim Dalı.
İlçol, Yeşim Özarda
Ulus, İsmail Hakkı
End stage renal disease
Rat corpus striatum
Medical laboratory technology
|Citation:||Özarda, Y. vd. (2002). "Free choline and phospholipid-bound choline concentrations in serum and dialysate during peritoneal dialysis in children and adults". Clinical Biochemistry, 35(4), 307-313.|
|Abstract:||Objectives: This study tested whether continuous ambulatory peritoneal dialysis (CAPD) changes free or phospholipid-bound choline concentrations in serum or peritoneal dialysis fluid of patients with end stage renal disease (ESRD). Design and methods: Serum and dialysate choline and phospholipid-bound choline were measured before, during and after 6 h CAPD. Results: Serum choline concentrations were higher in patients with ESRD compared with age-matched controls. CAPD lowered serum choline concentrations significantly although it did not influence phospholipid-bound choline. Choline accumulated in the dialysate, reaching 28.4 +/- 2.7 muM in children and 18.2 +/- 1.4 muM in adults, during six hours CAPD; phospholipid-bound choline increased to 22.9 +/- 2.5 muM and 10.8 +/- 1.4 muM in children and adults, respectively. The total daily loss of choline into the dialysate was 181 +/- 20 mumoles in children and 260 +/- 18 mumoles in adults. Conclusion: CAPD causes a substantial loss of choline into peritoneal dialysates and reduces serum choline concentrations significantly.|
|Appears in Collections:||Scopus|
Web of Science
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