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Title: Expression of p53 protein and prognosis in gastric carcinoma
Authors: Uludağ Üniversitesi/Tıp fakültesi/Gastroenteroloji Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.
Gürel, Selim
Dolar, Mahmut Enver
Yerci, Ömer
Samlı, Bülent
Öztürk, Hülya
Nak, Selim Giray
Gülten, Macit
Memik, Faruk
Keywords: Research & experimental medicine
Pharmacology & pharmacy
P53 protein
Gastric carcinoma
Clinicopathological features
Issue Date: 1999
Publisher: Cambridge Med Publ
Citation: Gürel, S. vd. (1999). "Expression of p53 protein and prognosis in gastric carcinoma". Journal of International Medical Research, 27(2), 85-89.
Abstract: A study was carried out to assess whether p53 expression is related to tumour type, grade or pathological characteristics, or to prognosis, in gastric cancer. Immunohistochemical studies were performed to detect p53 protein in sections from 55 consecutive gastrectomy or partial gastrectomy specimens. Tumours were classified for T-stage, histopathological grade and pathological characteristics. Immunohistochemical staining detected p53 protein in 11 (19%) of the 55 specimens. There was no statistically significant difference between patients with p53 positively staining tumours and patients with p53 negatively staining tumours with regard to tumour grade, stage or pathological characteristics (lymph-node infiltration, depth of invasion, necrosis, or necrosis of vessels). Survival time was statistically significantly lower in patients with positively staining tumours (mean survival times 12.0 and 23.4 months, respectively). These results suggest that expression of p53 protein is related to poor prognosis in gastric carcinoma.
ISSN: 0300-0605
Appears in Collections:Scopus
Web of Science

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