Beneficial effects of nigella sativa oil on intestinal damage in necrotizing enterocolitis
dc.contributor.author | Tayman, Cüneyt | |
dc.contributor.author | Çekmez, Ferhat | |
dc.contributor.author | Canpolat, Fuat Emre | |
dc.contributor.author | Çetinkaya, Merih | |
dc.contributor.author | Uysal, Sema | |
dc.contributor.author | Tunç, Turan | |
dc.contributor.author | Sarıcı, S. Ümit | |
dc.contributor.buuauthor | Kafa, İlker Mustafa | |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Anatomi Anabilim Dalı. | tr_TR |
dc.contributor.orcid | 0000-0001-8309-0934 | tr_TR |
dc.contributor.researcherid | AAG-7125-2021 | tr_TR |
dc.contributor.scopusid | 8450193200 | tr_TR |
dc.date.accessioned | 2022-09-27T11:08:31Z | |
dc.date.available | 2022-09-27T11:08:31Z | |
dc.date.issued | 2012-10 | |
dc.description.abstract | Aim: The aim of this study was to determine the beneficial effects of Nigella sativa oil (NSO) on rats with necrotizing enterocolitis (NEC). Material and Methods: Thirty newborn Sprague-Dawley rats were randomly divided into three groups as NEC, NEC + NSO, and control. NEC was induced by enteral formula feeding, exposure to hypoxia-hyperoxia and cold stress. Pups in the NEC + NSO group were administered NOS at a dose of 2 ml/kg daily by intraperitoneal route from the first day until the end of the study. Proximal colon and ileum were excised for histopathologic, apoptosis (TUNEL) and biochemical evaluation, including xanthine oxidase (XO), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), malonaldehyde (MDA), and myeloperoxdase (MPO) activities. Results: Pups in the NEC + NOS group had better clinical sickness scores and weight gain compared to the NEC group (p < 0.05). In the macroscopic assessment, histopathologic and apoptosis evaluation (TUNEL), severity of bowel damage was significantly lower in the NEC + NOS group compared to the NEC group (p < 0.05). Tissue GSH-Px and SOD levels were significantly preserved in the NEC + NSO group (p < 0.05), whereas, tissue MDA, MPO levels of the NEC + NSO group were significantly lower than those in the NEC group (p < 0.05). Conclusion: NSO significantly reduced the severity of intestinal damage in NEC. | en_US |
dc.description.sponsorship | GATA Military School of Medicine | en_US |
dc.description.sponsorship | Fatih University | en_US |
dc.identifier.citation | Tayman, C. vd. (2012). "Beneficial effects of nigella sativa oil on intestinal damage in necrotizing enterocolitis". Journal of Investigative Surgery, 25(5), 286-294. | en_US |
dc.identifier.endpage | 294 | tr_TR |
dc.identifier.issn | 0894-1939 | |
dc.identifier.issn | 1521-0553 | |
dc.identifier.issue | 5 | tr_TR |
dc.identifier.pubmed | 22571716 | tr_TR |
dc.identifier.scopus | 2-s2.0-84866994348 | tr_TR |
dc.identifier.startpage | 286 | tr_TR |
dc.identifier.uri | https://doi.org/10.3109/08941939.2011.639849 | tr_TR |
dc.identifier.uri | https://www.tandfonline.com/doi/full/10.3109/08941939.2011.639849 | en_US |
dc.identifier.uri | http://hdl.handle.net/11452/28847 | en_US |
dc.identifier.volume | 25 | tr_TR |
dc.identifier.wos | 000309452000003 | tr_TR |
dc.indexed.pubmed | Pubmed | en_US |
dc.indexed.scopus | Scopus | en_US |
dc.indexed.wos | SCIE | en_US |
dc.language.iso | en | en_US |
dc.publisher | Taylor & Francis | en_US |
dc.relation.collaboration | Yurt içi | tr_TR |
dc.relation.journal | Journal of Investigative Surgery | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | tr_TR |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Surgery | en_US |
dc.subject | Necrotizing enterocolitis | en_US |
dc.subject | Nigella sativa oil | en_US |
dc.subject | Protection | en_US |
dc.subject | Newborn | en_US |
dc.subject | Rat | en_US |
dc.subject | Ischemia-reperfusion injury | en_US |
dc.subject | Neonatal-rat model | en_US |
dc.subject | Epithelial apoptosis | en_US |
dc.subject | Lipid-peroxidation | en_US |
dc.subject | Barrier failure | en_US |
dc.subject | Nitric-oxide | en_US |
dc.subject | Seed | en_US |
dc.subject | Pathogenesis | en_US |
dc.subject | Management | en_US |
dc.subject | Colonization | en_US |
dc.subject.emtree | Glutathione peroxidase | en_US |
dc.subject.emtree | Malonaldehyde | en_US |
dc.subject.emtree | Myeloperoxidase | en_US |
dc.subject.emtree | Nigella sativa extract | en_US |
dc.subject.emtree | Nigella sativa oil | en_US |
dc.subject.emtree | Origo | en_US |
dc.subject.emtree | Superoxide dismutase | en_US |
dc.subject.emtree | Unclassified drug | en_US |
dc.subject.emtree | Xanthine oxidase | en_US |
dc.subject.emtree | Animal experiment | en_US |
dc.subject.emtree | Animal model | en_US |
dc.subject.emtree | Article | en_US |
dc.subject.emtree | Black cumin | en_US |
dc.subject.emtree | Controlled study | en_US |
dc.subject.emtree | Disease severity | en_US |
dc.subject.emtree | Drug effect | en_US |
dc.subject.emtree | Drug efficacy | en_US |
dc.subject.emtree | Necrotizing enterocolitis | en_US |
dc.subject.emtree | Newborn | en_US |
dc.subject.emtree | Nonhuman | tr_TR |
dc.subject.emtree | Priority journal | en_US |
dc.subject.emtree | Rat | en_US |
dc.subject.emtree | Treatment outcome | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Animals, newborn | en_US |
dc.subject.mesh | Antioxidants | en_US |
dc.subject.mesh | Apoptosis | en_US |
dc.subject.mesh | Colon | en_US |
dc.subject.mesh | Disease models, animal | en_US |
dc.subject.mesh | Enterocolitis, necrotizing | en_US |
dc.subject.mesh | Glutathione peroxidase | en_US |
dc.subject.mesh | Ileum | en_US |
dc.subject.mesh | Malondialdehyde | en_US |
dc.subject.mesh | Medicine, traditional | en_US |
dc.subject.mesh | Nigella sativa | en_US |
dc.subject.mesh | Peroxidase | en_US |
dc.subject.mesh | Phytotherapy | en_US |
dc.subject.mesh | Plant oils | en_US |
dc.subject.mesh | Rats | en_US |
dc.subject.mesh | Rats, sprague-dawley | en_US |
dc.subject.mesh | Superoxide dismutase | en_US |
dc.subject.mesh | Xanthine oxidase | en_US |
dc.subject.scopus | Necrotizing Enterocolitis; Prematurity; Intestine Perforation | en_US |
dc.subject.wos | Surgery | en_US |
dc.title | Beneficial effects of nigella sativa oil on intestinal damage in necrotizing enterocolitis | en_US |
dc.type | Article | |
dc.wos.quartile | Q3 | en_US |
Files
License bundle
1 - 1 of 1
No Thumbnail Available
- Name:
- license.txt
- Size:
- 1.71 KB
- Format:
- Item-specific license agreed upon to submission
- Description: