Beneficial effects of nigella sativa oil on intestinal damage in necrotizing enterocolitis

dc.contributor.authorTayman, Cüneyt
dc.contributor.authorÇekmez, Ferhat
dc.contributor.authorCanpolat, Fuat Emre
dc.contributor.authorÇetinkaya, Merih
dc.contributor.authorUysal, Sema
dc.contributor.authorTunç, Turan
dc.contributor.authorSarıcı, S. Ümit
dc.contributor.buuauthorKafa, İlker Mustafa
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Anatomi Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0001-8309-0934tr_TR
dc.contributor.researcheridAAG-7125-2021tr_TR
dc.contributor.scopusid8450193200tr_TR
dc.date.accessioned2022-09-27T11:08:31Z
dc.date.available2022-09-27T11:08:31Z
dc.date.issued2012-10
dc.description.abstractAim: The aim of this study was to determine the beneficial effects of Nigella sativa oil (NSO) on rats with necrotizing enterocolitis (NEC). Material and Methods: Thirty newborn Sprague-Dawley rats were randomly divided into three groups as NEC, NEC + NSO, and control. NEC was induced by enteral formula feeding, exposure to hypoxia-hyperoxia and cold stress. Pups in the NEC + NSO group were administered NOS at a dose of 2 ml/kg daily by intraperitoneal route from the first day until the end of the study. Proximal colon and ileum were excised for histopathologic, apoptosis (TUNEL) and biochemical evaluation, including xanthine oxidase (XO), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), malonaldehyde (MDA), and myeloperoxdase (MPO) activities. Results: Pups in the NEC + NOS group had better clinical sickness scores and weight gain compared to the NEC group (p < 0.05). In the macroscopic assessment, histopathologic and apoptosis evaluation (TUNEL), severity of bowel damage was significantly lower in the NEC + NOS group compared to the NEC group (p < 0.05). Tissue GSH-Px and SOD levels were significantly preserved in the NEC + NSO group (p < 0.05), whereas, tissue MDA, MPO levels of the NEC + NSO group were significantly lower than those in the NEC group (p < 0.05). Conclusion: NSO significantly reduced the severity of intestinal damage in NEC.en_US
dc.description.sponsorshipGATA Military School of Medicineen_US
dc.description.sponsorshipFatih Universityen_US
dc.identifier.citationTayman, C. vd. (2012). "Beneficial effects of nigella sativa oil on intestinal damage in necrotizing enterocolitis". Journal of Investigative Surgery, 25(5), 286-294.en_US
dc.identifier.endpage294tr_TR
dc.identifier.issn0894-1939
dc.identifier.issn1521-0553
dc.identifier.issue5tr_TR
dc.identifier.pubmed22571716tr_TR
dc.identifier.scopus2-s2.0-84866994348tr_TR
dc.identifier.startpage286tr_TR
dc.identifier.urihttps://doi.org/10.3109/08941939.2011.639849tr_TR
dc.identifier.urihttps://www.tandfonline.com/doi/full/10.3109/08941939.2011.639849en_US
dc.identifier.urihttp://hdl.handle.net/11452/28847en_US
dc.identifier.volume25tr_TR
dc.identifier.wos000309452000003tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherTaylor & Francisen_US
dc.relation.collaborationYurt içitr_TR
dc.relation.journalJournal of Investigative Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSurgeryen_US
dc.subjectNecrotizing enterocolitisen_US
dc.subjectNigella sativa oilen_US
dc.subjectProtectionen_US
dc.subjectNewbornen_US
dc.subjectRaten_US
dc.subjectIschemia-reperfusion injuryen_US
dc.subjectNeonatal-rat modelen_US
dc.subjectEpithelial apoptosisen_US
dc.subjectLipid-peroxidationen_US
dc.subjectBarrier failureen_US
dc.subjectNitric-oxideen_US
dc.subjectSeeden_US
dc.subjectPathogenesisen_US
dc.subjectManagementen_US
dc.subjectColonizationen_US
dc.subject.emtreeGlutathione peroxidaseen_US
dc.subject.emtreeMalonaldehydeen_US
dc.subject.emtreeMyeloperoxidaseen_US
dc.subject.emtreeNigella sativa extracten_US
dc.subject.emtreeNigella sativa oilen_US
dc.subject.emtreeOrigoen_US
dc.subject.emtreeSuperoxide dismutaseen_US
dc.subject.emtreeUnclassified drugen_US
dc.subject.emtreeXanthine oxidaseen_US
dc.subject.emtreeAnimal experimenten_US
dc.subject.emtreeAnimal modelen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeBlack cuminen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeDisease severityen_US
dc.subject.emtreeDrug effecten_US
dc.subject.emtreeDrug efficacyen_US
dc.subject.emtreeNecrotizing enterocolitisen_US
dc.subject.emtreeNewbornen_US
dc.subject.emtreeNonhumantr_TR
dc.subject.emtreePriority journalen_US
dc.subject.emtreeRaten_US
dc.subject.emtreeTreatment outcomeen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnimals, newbornen_US
dc.subject.meshAntioxidantsen_US
dc.subject.meshApoptosisen_US
dc.subject.meshColonen_US
dc.subject.meshDisease models, animalen_US
dc.subject.meshEnterocolitis, necrotizingen_US
dc.subject.meshGlutathione peroxidaseen_US
dc.subject.meshIleumen_US
dc.subject.meshMalondialdehydeen_US
dc.subject.meshMedicine, traditionalen_US
dc.subject.meshNigella sativaen_US
dc.subject.meshPeroxidaseen_US
dc.subject.meshPhytotherapyen_US
dc.subject.meshPlant oilsen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, sprague-dawleyen_US
dc.subject.meshSuperoxide dismutaseen_US
dc.subject.meshXanthine oxidaseen_US
dc.subject.scopusNecrotizing Enterocolitis; Prematurity; Intestine Perforationen_US
dc.subject.wosSurgeryen_US
dc.titleBeneficial effects of nigella sativa oil on intestinal damage in necrotizing enterocolitisen_US
dc.typeArticle
dc.wos.quartileQ3en_US

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