Intravenous dexmedetomidine, but not midazolam, prolongs bupivacaine spinal anesthesia
dc.contributor.buuauthor | Kaya, Fatma Nur | |
dc.contributor.buuauthor | Yavaşçaoğlu, Belgin | |
dc.contributor.buuauthor | Türker, Gürkan | |
dc.contributor.buuauthor | Yıldırım, Arzu | |
dc.contributor.buuauthor | Gurbet, Alp | |
dc.contributor.buuauthor | Moğol, Elif Başağan | |
dc.contributor.buuauthor | Özcan, Berin | |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Anesteziyoloji ve Reanimasyon Anabilim Dalı. | tr_TR |
dc.contributor.orcid | 0000-0002-6503-8232 | tr_TR |
dc.contributor.orcid | 0000-0002-3019-581X | tr_TR |
dc.contributor.researcherid | AAI-7914-2021 | tr_TR |
dc.contributor.researcherid | AAI-8213-2021 | tr_TR |
dc.contributor.researcherid | AAG-9356-2021 | tr_TR |
dc.contributor.researcherid | A-7994-2018 | tr_TR |
dc.contributor.researcherid | AAI-6642-2021 | tr_TR |
dc.contributor.scopusid | 7003619647 | tr_TR |
dc.contributor.scopusid | 6602742300 | tr_TR |
dc.contributor.scopusid | 7003400116 | tr_TR |
dc.contributor.scopusid | 35799165100 | tr_TR |
dc.contributor.scopusid | 35618853300 | tr_TR |
dc.contributor.scopusid | 23982134100 | tr_TR |
dc.contributor.scopusid | 6603825848 | tr_TR |
dc.date.accessioned | 2021-11-17T10:58:17Z | |
dc.date.available | 2021-11-17T10:58:17Z | |
dc.date.issued | 2010-01 | |
dc.description.abstract | Midazolam has only sedative properties. However, dexmedetomidine has both analgesic and sedative properties that may prolong the duration of sensory and motor block obtained with spinal anesthesia. This study was designed to compare intravenous dexmedetomidine with midazolam and placebo on spinal block duration, analgesia, and sedation in patients undergoing transurethral resection of the prostate. In this double-blind randomized placebo-controlled trial, 75 American Society of Anesthesiologists' I and II patients received dexmedetomidine 0.5 mu g center dot A kg(-1), midazolam 0.05 mg center dot A kg(-1), or saline intravenously before spinal anesthesia with bupivacaine 0.5% 15 mg (n = 25 per group). The maximum upper level of sensory block and sensory and motor regression times were recorded. Postoperative analgesic requirements and sedation were also recorded. Sensory block was higher with dexmedetomidine (T 4.6 +/- A 0.6) than with midazolam (T 6.4 +/- A 0.9; P < 0.001) or saline (T 6.4 +/- A 0.8; P < 0.001). Time for sensory regression of two dermatomes was 145 +/- A 26 min in the dexmedetomidine group, longer (P < 0.001) than in the midazolam (106 +/- A 39 min) or the saline (97 +/- A 27 min) groups. Duration of motor block was similar in all groups. Dexmedetomidine also increased the time to first request for postoperative analgesia (P < 0.01 compared with midazolam and saline) and decreased analgesic requirements (P < 0.05). The maximum Ramsay sedation score was greater in the dexmedetomidine and midazolam groups than in the saline group (P < 0.001). Intravenous dexmedetomidine, but not midazolam, prolonged spinal bupivacaine sensory blockade. It also provided sedation and additional analgesia. | en_US |
dc.identifier.citation | Kaya, F. N. vd. (2010). "Intravenous dexmedetomidine, but not midazolam, prolongs bupivacaine spinal anesthesia". Canadian Journal of Anaesthesia - Journal Canadien D Anesthesie, 57(1), 39-45. | en_US |
dc.identifier.endpage | 45 | tr_TR |
dc.identifier.issn | 0832-610X | |
dc.identifier.issue | 1 | tr_TR |
dc.identifier.pubmed | 20039221 | tr_TR |
dc.identifier.scopus | 2-s2.0-74349096562 | tr_TR |
dc.identifier.startpage | 39 | tr_TR |
dc.identifier.uri | https://doi.org/10.1007/s12630-009-9231-6 | |
dc.identifier.uri | https://link.springer.com/article/10.1007/s12630-009-9231-6 | |
dc.identifier.uri | http://hdl.handle.net/11452/22689 | |
dc.identifier.volume | 57 | tr_TR |
dc.identifier.wos | 000273399600006 | tr_TR |
dc.indexed.pubmed | Pubmed | en_US |
dc.indexed.scopus | Scopus | en_US |
dc.indexed.wos | SCIE | en_US |
dc.language.iso | en | en_US |
dc.publisher | Springer | en_US |
dc.relation.journal | Canadian Journal of Anaesthesia-Journal Canadien D Anesthesie | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | tr_TR |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Dose dexmedetomidine | en_US |
dc.subject | Regional ansthesia | en_US |
dc.subject | Premedication | en_US |
dc.subject | Clonidine | en_US |
dc.subject | Surgery | en_US |
dc.subject | Sedation | en_US |
dc.subject | Requirement | en_US |
dc.subject | Analgesia | en_US |
dc.subject | Infusion | en_US |
dc.subject | Humans | en_US |
dc.subject | Anesthesiology | en_US |
dc.subject.emtree | Atropine | en_US |
dc.subject.emtree | Bupivacaine | en_US |
dc.subject.emtree | Dexmedetomidine | en_US |
dc.subject.emtree | Diclofenac | en_US |
dc.subject.emtree | Ephedrine | en_US |
dc.subject.emtree | Infusion fluid | en_US |
dc.subject.emtree | Midazolam | en_US |
dc.subject.emtree | Placebo | en_US |
dc.subject.emtree | Adult | en_US |
dc.subject.emtree | Article | en_US |
dc.subject.emtree | Bradycardia | en_US |
dc.subject.emtree | Breathing rate | en_US |
dc.subject.emtree | Clinical trial | en_US |
dc.subject.emtree | Controlled clinical trial | en_US |
dc.subject.emtree | Controlled study | en_US |
dc.subject.emtree | Dermatome | en_US |
dc.subject.emtree | Double blind procedure | en_US |
dc.subject.emtree | End tidal carbon dioxide tension | en_US |
dc.subject.emtree | Heart rate | en_US |
dc.subject.emtree | Human | en_US |
dc.subject.emtree | Hypotension | en_US |
dc.subject.emtree | Major clinical study | en_US |
dc.subject.emtree | Mean arterial pressure | en_US |
dc.subject.emtree | Operation duration | en_US |
dc.subject.emtree | Oxygen saturation | en_US |
dc.subject.emtree | Postoperative analgesia | en_US |
dc.subject.emtree | Premedication | en_US |
dc.subject.emtree | Priority journal | en_US |
dc.subject.emtree | Randomized controlled trial | en_US |
dc.subject.emtree | Respiration depression | en_US |
dc.subject.emtree | Sedation | en_US |
dc.subject.emtree | Side effect | en_US |
dc.subject.emtree | Single drug dose | en_US |
dc.subject.emtree | Spinal anesthesia | en_US |
dc.subject.emtree | Surgical patient | en_US |
dc.subject.emtree | Systolic blood pressure | en_US |
dc.subject.emtree | Transurethral resection | en_US |
dc.subject.mesh | Aged | en_US |
dc.subject.mesh | Anesthesia, spinal | en_US |
dc.subject.mesh | Anesthetics, combined | en_US |
dc.subject.mesh | Anesthetics, local | en_US |
dc.subject.mesh | Bupivacaine | en_US |
dc.subject.mesh | Dexmedetomidine | en_US |
dc.subject.mesh | Double-blind method | en_US |
dc.subject.mesh | Drug synergism | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Hypnotics and sedatives | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Midazolam | en_US |
dc.subject.mesh | Middle aged | en_US |
dc.subject.mesh | Nerve block | en_US |
dc.subject.mesh | Time factors | en_US |
dc.subject.mesh | Transurethralresection of prostate | en_US |
dc.subject.scopus | Dexmedetomidine; Sedation; Adrenergic Receptor Blocking Agent | en_US |
dc.subject.wos | Anesthesiology | en_US |
dc.title | Intravenous dexmedetomidine, but not midazolam, prolongs bupivacaine spinal anesthesia | en_US |
dc.type | Article | |
dc.wos.quartile | Q2 | en_US |