One-pot synthesis and hydrokylaminolysis of asymmetrical acyclic nitrones
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Date
2005
Authors
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Journal ISSN
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Publisher
Taylor & Francis
Abstract
Aromatic aldehydes were reductively aminated to the corresponding secondary amines using NaBH4 in methanol in good yields. Amines were oxidized with H2O2-WO42- regioselectively to nitrones, the structures of which were easily determined by reacting them with hydroxylamine hydrochloride as well as by spectral means. The products of hydroxylaminolysis in ether proved to be the corresponding benzaldehyde oximes and benzyl or methyl hydroxylamine hydrochlorides.
Description
Keywords
Acyclic nitrone, Oxidation, Alkyl hydroxylamine hydrochloride, 1,3-Dipolar cycloaddition, Oxidation, Imidazoline 3-oxides, Hydrogen-peroxide, Diastereoselective addition, Secondary-amines, Regio, Hydroxylamines, Chemistry
Citation
Coşkun, N. ve Parlar, A. (2005). "One-pot synthesis and hydrokylaminolysis of asymmetrical acyclic nitrones". Synthetic Communications, 35(18), 2445-2451.