The relation between oxidant and antioxidant parameters and severity of acute coronary syndromes

dc.contributor.buuauthorSerdar, Zehra
dc.contributor.buuauthorSerdar, Akın
dc.contributor.buuauthorAltın, Aysun
dc.contributor.buuauthorEryılma, Ufuk
dc.contributor.buuauthorAlbayrak, Sezgin
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Kardiyoloji Anabilim Dalı.tr_TR
dc.contributor.scopusid57222002284tr_TR
dc.contributor.scopusid6603403111tr_TR
dc.contributor.scopusid17134032300tr_TR
dc.contributor.scopusid19933368700tr_TR
dc.contributor.scopusid19933747500tr_TR
dc.date.accessioned2022-09-14T11:36:13Z
dc.date.available2022-09-14T11:36:13Z
dc.date.issued2007-08
dc.description.abstractObjective -Acute coronary syndromes (ACS) encompass a continuum of cardiac ischaemic events, ranging from unstable angina pectoris (UA) to ST-segment elevation myocardial infarction (STEMI). Oxidative stress may play an important role in the pathogenesis of acute coronary diseases. In the present study, we examined the associations between lipid and protein susceptibility to oxidation and total sialic acid (SA) and antioxidant status and the severity of ACS as determined by having UA, non-STEMI or STEMI. Methods and results - The study sample consisted of 102 patients with ACS and 45 controls. Malondialclehyde (MDA) as a marker of lipid peroxiclation and protein carbonyls as a marker of protein oxidation were measured to show the susceptibility to oxidation. Antioxidant status was determined by measuring the carotenoids, vitamin C and vitamin E levels and paraoxonase and arylesterase activities. In addition to conventional lipid and lipoprotein analysis, MDA and vitamin E were quantitated by high-performance liquid chromatography. Total SA and other oxidant and antioxidant parameters were studied spectrophotometrically. As expected, patients had significantly higher total cholesterol, triacylglycerol, low-density lipoprotein cholesterol, lipoprotein (a), apolipoprotein (apo) B values and lower high-density lipoprotein cholesterol and apoAl values than controls. Our results demonstrated significant increases both in total SA levels and in indicators of oxidative stress in patients with ACS compared with the controls. However, antioxidant parameters were decreased in patients with ACS. When the patients were divided into groups with UA, non-STEMI and STEMI, respectively, total SA and oxidant parameters were significantly increased and antioxidant parameters were significantly decreased in going from UA to STEMI. Conclusions - Our study shows gradually increased lipid and protein oxidation and total SA and gradually decreased antioxidant status when the conditions advance from UA to STEMI. These results indicate that these markers may be useful both in understanding plaque destabilization and in determination of risk stratification of patients. Also, measurement of these markers may provide a non-invasive window to study atherosclerotic lesions.en_US
dc.identifier.citationSerdar, Z. vd. (2007). "The relation between oxidant and antioxidant parameters and severity of acute coronary syndromes". Acta Cardiologia, 62(4), 373-380.en_US
dc.identifier.endpage380tr_TR
dc.identifier.issn0001-5385
dc.identifier.issn1784-973X
dc.identifier.issue4tr_TR
dc.identifier.pubmed17824298tr_TR
dc.identifier.scopus2-s2.0-34548161430tr_TR
dc.identifier.startpage373tr_TR
dc.identifier.urihttps://doi.org/10.2143/AC.62.4.2022281
dc.identifier.urihttps://poj.peeters-leuven.be/content.php?url=article&id=2022281&journal_code=AC
dc.identifier.urihttp://hdl.handle.net/11452/28718
dc.identifier.volume62tr_TR
dc.identifier.wos000249097300009tr_TR
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherTaylor & Francisen_US
dc.relation.journalActa Cardiologicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTotal sialic aciden_US
dc.subjectSerum paraoxonase arylesteraen_US
dc.subjectAcute coronary syndromeen_US
dc.subjectCarotenoidsen_US
dc.subjectMalondialdehydeen_US
dc.subjectParaoxonaseen_US
dc.subjectProtein carbonylsen_US
dc.subjectVitamin Cen_US
dc.subjectVitamin Een_US
dc.subjectSesialic-aciden_US
dc.subjectOxidative stressen_US
dc.subjectPlasma-levelsen_US
dc.subjectFree-radicalsen_US
dc.subjectPathogenesisen_US
dc.subjectProteinsen_US
dc.subjectDiseaseen_US
dc.subjectDamageen_US
dc.subjectSusceptibilityen_US
dc.subject.emtreeAgeden_US
dc.subject.emtreeHeart infarctionen_US
dc.subject.emtreeAcute coronary syndromeen_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeAgeden_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeCholesterol blood levelen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeDisease severityen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeHigh performance liquid chromatographyen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeLipid peroxidationen_US
dc.subject.emtreeMajor clinical studyen_US
dc.subject.emtreeProtein blood levelen_US
dc.subject.emtreeSpectrofluorometryen_US
dc.subject.emtreeOxidative stressen_US
dc.subject.emtreeParameteren_US
dc.subject.emtreeRisk factoren_US
dc.subject.emtreeST segment elevationen_US
dc.subject.emtreeUnstable angina pectorisen_US
dc.subject.emtreeVitamin blood levelen_US
dc.subject.emtreeProtein analysisen_US
dc.subject.emtreeAntioxidantsen_US
dc.subject.emtreeAnalysis of varianceen_US
dc.subject.emtreeAngina, unstableen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeAryldialkylphosphataseen_US
dc.subject.emtreeBiological markersen_US
dc.subject.emtreeCarboxylic ester hydrolasesen_US
dc.subject.emtreeCase-control studiesen_US
dc.subject.emtreeChromatography, high pressure liquiden_US
dc.subject.emtreeFollow-up studiesen_US
dc.subject.emtreeOxidantsen_US
dc.subject.emtreeHumansen_US
dc.subject.emtreeLipid peroxidationen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeMalondialdehydeen_US
dc.subject.emtreeMiddle ageden_US
dc.subject.emtreeMyocardial infarctionen_US
dc.subject.emtreeN-Acetylneuraminic aciden_US
dc.subject.emtreeSeverity of illness indexen_US
dc.subject.emtreeOxidative stressen_US
dc.subject.emtreeProtein carbonylationen_US
dc.subject.meshBiological markersen_US
dc.subject.meshAcute coronary syndromeen_US
dc.subject.meshAgeden_US
dc.subject.meshAnalysis of varianceen_US
dc.subject.meshAngina, unstableen_US
dc.subject.meshAntioxidantsen_US
dc.subject.meshAryldialkylphosphataseen_US
dc.subject.meshMaleen_US
dc.subject.meshN-Acetylneuraminic aciden_US
dc.subject.meshCarboxylic ester hydrolasesen_US
dc.subject.meshCase-control studiesen_US
dc.subject.meshChromatography, high pressure liquiden_US
dc.subject.meshFemaleen_US
dc.subject.meshFollow-up studiesen_US
dc.subject.meshHumansen_US
dc.subject.meshLipid peroxidationen_US
dc.subject.meshOxidantsen_US
dc.subject.meshMalondialdehydeen_US
dc.subject.meshMiddle ageden_US
dc.subject.meshMyocardial infarctionen_US
dc.subject.meshSeverity of illness indexen_US
dc.subject.meshOxidative stressen_US
dc.subject.meshProtein carbonylationen_US
dc.subject.scopusSialic Acids; Glycoconjugates; Fucoseen_US
dc.subject.wosCardiac & cardiovascular systemsen_US
dc.titleThe relation between oxidant and antioxidant parameters and severity of acute coronary syndromesen_US
dc.typeArticle
dc.wos.quartileQ4en_US

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