Evaluation of anti-oxidative, genotoxic and antigenotoxic potency of codium tomentosum stackhouse ethanolic extract in human lymphocytes in vitro
dc.contributor.buuauthor | Çelikler, Serap | |
dc.contributor.buuauthor | Vatan, Özgür | |
dc.contributor.buuauthor | Yıldız, Gamze | |
dc.contributor.buuauthor | Bilaloğlu, Rahmi | |
dc.contributor.department | Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Biyoloji Bölümü. | tr_TR |
dc.contributor.orcid | 0000-0002-7687-3284 | tr_TR |
dc.contributor.orcid | 0000-0002-4177-3478 | tr_TR |
dc.contributor.researcherid | A-9944-2010 | tr_TR |
dc.contributor.researcherid | O-7508-2015 | tr_TR |
dc.contributor.researcherid | AAH-2767-2021 | tr_TR |
dc.contributor.scopusid | 8234554800 | tr_TR |
dc.contributor.scopusid | 16235098100 | tr_TR |
dc.contributor.scopusid | 6701743065 | tr_TR |
dc.contributor.scopusid | 6505804122 | tr_TR |
dc.date.accessioned | 2021-12-02T12:20:09Z | |
dc.date.available | 2021-12-02T12:20:09Z | |
dc.date.issued | 2009-04 | |
dc.description.abstract | The genome is constantly exposed to agents, both exogenous and endogenous, that damage DNA. Consequently, it is very important that determination of this agents and the protective agents. In this work, we evaluated the antigenotoxic/antimutagenic activity of the crude ethanolic extracts of Codium tomentosurn Stackhouse (Chlorophyceae) (CTE), collected from The Coast of South East Marmara Sea, in human lymphocytes culture in vitro against genotoxic/mutagenic agents MMC, EMS and H2O2 by using chromosome aberration (CA), sister chromatid exchange (SCE) and micronuclei (MN) assays as experimental endpoints. Also, in the present study, we determined total phenolic content and total antioxidant capacity (in soluble lipid and water). In addition, total protein, total carbohydrate, vitamins (A. C and E) and pigments (chlorophyll a, chlorophyll b and carotene) contents were also determined. Results of CA, SCE and MN tests show that CTEs have not shown genotoxic effect. In CTE plus MMC-. EMS- or H2O2- treated cultures, CA, SCE and MN frequency which induced by MMC, EMS or H2O2 has been decreased significantly (p < 0.05-0.001). This is the first report on genotoxicity/antigenotoxicity and anti-oxidative capacity of Codium tomentosum. Our results have clearly shown that CTE has strong anti-oxidative and antigenotoxic effect. | en_US |
dc.identifier.citation | Çelikler, S. vd. (2009). "Evaluation of anti-oxidative, genotoxic and antigenotoxic potency of codium tomentosum stackhouse ethanolic extract in human lymphocytes in vitro". Food and Chemical Toxicology, 47(4), 796-801. | en_US |
dc.identifier.endpage | 801 | tr_TR |
dc.identifier.issn | 0278-6915 | |
dc.identifier.issue | 4 | tr_TR |
dc.identifier.pubmed | 19167449 | tr_TR |
dc.identifier.scopus | 2-s2.0-60849096069 | tr_TR |
dc.identifier.startpage | 796 | tr_TR |
dc.identifier.uri | https://doi.org/10.1016/j.fct.2009.01.010 | |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0278691509000180 | |
dc.identifier.uri | http://hdl.handle.net/11452/22967 | |
dc.identifier.volume | 47 | tr_TR |
dc.identifier.wos | 000264623000019 | tr_TR |
dc.indexed.pubmed | Pubmed | en_US |
dc.indexed.scopus | Scopus | en_US |
dc.indexed.wos | SCIE | en_US |
dc.language.iso | en | en_US |
dc.publisher | Pergamon-Elsevier Science | en_US |
dc.relation.journal | Food and Chemical Toxicology | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | tr_TR |
dc.relation.tubitak | TÜBİTAK (107T279) | tr_TR |
dc.relation.tubitak | TÜBİTAK (TBAG/HD-304) | tr_TR |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Anti-oxidative effect | en_US |
dc.subject | CA | en_US |
dc.subject | Codium tomentosum | en_US |
dc.subject | MN | en_US |
dc.subject | Oxidative and chromosome damage | en_US |
dc.subject | SCE | en_US |
dc.subject | Antiproliferative activities | en_US |
dc.subject | Antibacterial activity | en_US |
dc.subject | Marine-algae | en_US |
dc.subject | Red alga | en_US |
dc.subject | Dietary | en_US |
dc.subject | Seaweed | en_US |
dc.subject | Dna | en_US |
dc.subject | Micronuclei | en_US |
dc.subject | Induction | en_US |
dc.subject | Products | en_US |
dc.subject | Food science & technology | en_US |
dc.subject | Toxicology | en_US |
dc.subject | Chlorophyceae | en_US |
dc.subject | Codium tomentosum | en_US |
dc.subject.emtree | Alpha tocopherol | en_US |
dc.subject.emtree | Ascorbic acid | en_US |
dc.subject.emtree | Carbohydrate | en_US |
dc.subject.emtree | Carotene | en_US |
dc.subject.emtree | Chlorophyll a | en_US |
dc.subject.emtree | Chlorophyll b | en_US |
dc.subject.emtree | Codium tomentosum stackhouse extract | en_US |
dc.subject.emtree | Hydrogen peroxide | en_US |
dc.subject.emtree | Lipid | en_US |
dc.subject.emtree | Mesylic acid ethyl ester | en_US |
dc.subject.emtree | Mitomycin C | en_US |
dc.subject.emtree | Phenol | en_US |
dc.subject.emtree | Plant extract | en_US |
dc.subject.emtree | Retinol | en_US |
dc.subject.emtree | Unclassified drug | en_US |
dc.subject.emtree | Water | en_US |
dc.subject.emtree | Adult | en_US |
dc.subject.emtree | Antioxidant activity | en_US |
dc.subject.emtree | Article | en_US |
dc.subject.emtree | Cell level | en_US |
dc.subject.emtree | Chlorophyll content | en_US |
dc.subject.emtree | Chromosome aberration | en_US |
dc.subject.emtree | Codium tomentosum Stackhouse | en_US |
dc.subject.emtree | Controlled study | en_US |
dc.subject.emtree | Drug effect | en_US |
dc.subject.emtree | Drug isolation | en_US |
dc.subject.emtree | Drug potency | en_US |
dc.subject.emtree | Drug screening | en_US |
dc.subject.emtree | Female | en_US |
dc.subject.emtree | Genotoxicity | en_US |
dc.subject.emtree | Human | en_US |
dc.subject.emtree | Human cell | en_US |
dc.subject.emtree | In vitro study | en_US |
dc.subject.emtree | Lymphocyte | en_US |
dc.subject.emtree | Lymphocyte culture | en_US |
dc.subject.emtree | Male | en_US |
dc.subject.emtree | Micronucleus test | en_US |
dc.subject.emtree | Normal human | en_US |
dc.subject.emtree | Protein content | en_US |
dc.subject.emtree | Seaweed | en_US |
dc.subject.emtree | Sister chromatid exchange | en_US |
dc.subject.mesh | Adolescent | en_US |
dc.subject.mesh | Adult | en_US |
dc.subject.mesh | Algae, green | en_US |
dc.subject.mesh | Antimutagenic agents | en_US |
dc.subject.mesh | Antioxidants | en_US |
dc.subject.mesh | Chromosome aberrations | en_US |
dc.subject.mesh | DNA damage | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Lymphocytes | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Mutagens | en_US |
dc.subject.mesh | Sister chromatid exchange | en_US |
dc.subject.scopus | Seaweeds; Padina; Ulva | en_US |
dc.subject.wos | Food science & technology | en_US |
dc.subject.wos | Toxicology | en_US |
dc.title | Evaluation of anti-oxidative, genotoxic and antigenotoxic potency of codium tomentosum stackhouse ethanolic extract in human lymphocytes in vitro | en_US |
dc.type | Article | |
dc.wos.quartile | Q1 (Food science & technology) | en_US |
dc.wos.quartile | Q3 (Toxicology) | en_US |