Effect of high fructose corn sirup on pancreatic ductal adenocarcinoma induced by dimethyl benzantracene (DMBA) in rats
Date
2020-05-12
Authors
İnan, Sevda
Akgül, Mustafa Barış
Bağdaş, Deniz
Journal Title
Journal ISSN
Volume Title
Publisher
Routledge Journals
Abstract
Increased risk of pancreatic cancer may be associated with consumption of sugar containing foods. The aim of this study was to evaluate the effect of peach nectar containing high fructose corn sirup (HFCS) consumption in a pancreatic carcinogenesis rat model induced by 7,12-Dimethyl benzanthracene (DMBA). Fifty-day-old male Sprague Dawley rats were fed with peach nectar containing HFCS + chow, peach nectar containing sucrose + chow and only chow. After 8 mo, feeding period, each group was divided into two subgroups, in which the rats were implanted with DMBA and no DMBA (sham). Histologic specimens were evaluated according to the routine tissue processing protocol. The animals withad libitumaccess to pn-HFCS, pn-sucrose and chow (only) showed significant differences in chow consumption and glucose level. Necropsy and histopathologic findings showed tumor formation in the entire group treated with DMBA. Excluding one rat in chow group, which was classified as poorly differentiated type, the others were classified as moderately differentiated pancreatic ductal adenocarcinoma (PDAC). This study demonstrated that daily intake of HFCS did not increase body weight and there was no effect of peach nectar consumption on the development of PDAC induced by DMBA in rats.
Description
Keywords
Normal dietary consumption, Cancer-risk, Insulin-resistance, Pooled analysis, Intraepithelial neoplasia, Glycemic load, Body-weight, Glucose, Obesity, Sugar, Oncology, Nutrition & dietetics
Citation
Sinir-Özcan, G. vd. (2021). "Effect of high fructose corn sirup on pancreatic ductal adenocarcinoma induced by dimethyl benzantracene (DMBA) in rats". Nutrition and Cancer, 73(2), 339-349.